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Clinical Interventions in Aging Volume 14, 2019 - Issue
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Original Research

Carotid artery calcification score and its association with cognitive impairment

Zhou ChuDepartment of Vascular Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu, China, [email protected]
,
Liu ChengDepartment of Vascular Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu, China, [email protected]
&
Qiao TongDepartment of Vascular Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu, China, [email protected]Correspondence[email protected]
Pages 167-177 | Published online: 18 Jan 2019

Figures & data

Table 1 Baseline characteristics of enrolled CAS patients and normal control group

Figure 1 Linear relationship of ln(CS +1) with cognitive scores.

Notes: (A) Pearson correlation analysis of ln(CS +1) and cognitive score in CAS patient, R=−0.359, P<0.001; (B) Pearson correlation analysis of ln(CS +1) and cognitive score in postoperative patients with CEA, R=−0.079, P=0.091.
Abbreviations: CAS, carotid artery stenosis; CEA, carotid endarterectomy; CS, calcification score.
Figure 1 Linear relationship of ln(CS +1) with cognitive scores.

Figure 2 ANOVA of CS value.

Notes: (A) One-way ANOVA of CS value with different cognitive groups indicated that CS had significant differential expression in the 3 groups, P=0.019. *P=0.05; (B) ANOVA of CS value with different stenosis degree groups, P=0.097.
Abbreviation: CS, calcification score.
Figure 2 ANOVA of CS value.

Table 2 Person correlation analysis of ln(CS +1) and stenosis degree, plaque burden morphological parameters (LA, WA, TVA and PB)

Table 3 Chi-squared test of histological parameters of different CS groups

Figure 3 ROC curve of CS value’s prediction of carotid histological parameters.

Notes: (A) CS value’s prediction of IPH, P=0.156, AUC =0.658; (B) CS value’s prediction of LRNC, P=0.029, AUC =0.780; (C) CS value’s prediction of FCSR, P=0.729; AUC =0.051.
Abbreviations: AUC, area under the curve; CS, calcification score; FCSR, fibrous cap surface rupture; IPH, intraplaque hemorrhage; LRNC, lipid-rich necrotic nucleus; ROC, receiver operating characteristic.
Figure 3 ROC curve of CS value’s prediction of carotid histological parameters.

Figure 4 Change in MMSE and MoCA pre- and post-CEA (X ± S).

Notes: (A) MoCA Post-CEA: P=0.042. (B) MoCA sub-tests: visuo-executive: P=0.026; Naming: P=0.029; Attention: P=0.032; Abstraction: P=0.017. (C) MMSE sub-tests: Recall: P=0.021. *P<0.05.
Abbreviations: CEA, carotid endarterectomy; MMSE, Mini–Mental State Examination; MoCA, Montreal Cognitive Assessment.
Figure 4 Change in MMSE and MoCA pre- and post-CEA (X ± S).

Figure S1 Carotid plaque calcium staining. Stained deposition of calcium presented as black annular, and plaque rupture occurred in the “right shoulder” of fibrous cap.

Figure S1 Carotid plaque calcium staining. Stained deposition of calcium presented as black annular, and plaque rupture occurred in the “right shoulder” of fibrous cap.

Table S1 Paired sample test results of the two physicians’ analysis

Table S2 Baseline characteristics of left and right CAS patients

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