Figures & data
Figure 1 Flowchart depicting the literature search process.
Table 1 Association of gene polymorphism with therapy response
Figure 2 Possible mechanism of polymorphisms in ChAT and CHRNA7 affecting ChEI cognitive response.
Notes: ChEI increases the levels of acetylcholine, which binds the alpha-7 nAChR encoded by CHRNA7. The effect of polymorphisms in ChAT with AChEI therapy response is associated with the synthesis capacity of the remaining cholinergic neurons to favor the response to AChEIs. The polymorphism effect of CHRNA7 on the therapeutic response may be through 1) modulation of the release of the neurotransmitters in presynaptic neurons, 2) memory enhancement by modulation of cholinergic neurotransmission, 3) neuroprotection through the alpha-7 nAChR, 4) regulation enhancement of apha-7 nAChR by ChEI, and 5) positive allosteric modulation of galantamine-mediated at the apha-7 nAChR.
Abbreviations: ChAT, choline acetyltransferase; ChEI, cholinesterase inhibitor; SNP, single nucleotide polymorphism.
Abbreviations: ChAT, choline acetyltransferase; ChEI, cholinesterase inhibitor; SNP, single nucleotide polymorphism.
Figure 3 The role of SNAP-25 in presynapse.
Note: (A) Presynaptic effect of SNAP-25 on VGCCs and (B) the role of SNAP-25 in Ca2+-mediated vesicle fusion.
Abbreviations: SNAP-25, synaptosomal-associated protein of 25 kDa; SNP, single nucleotide polymorphism; VGCCs, voltage-gated calcium channels.
Abbreviations: SNAP-25, synaptosomal-associated protein of 25 kDa; SNP, single nucleotide polymorphism; VGCCs, voltage-gated calcium channels.
Table 2 Illustration of occurrence of polymorphism in healthy individuals