Changes in the blood antioxidant defense of advanced age people

Figures & data

Table 1 Anthropometric parameters of the examined groups (mean ± SD)

Parameter	55–59 years	65–69 years	70–74 years	75–79 years	80–84 years	85–89 years	90+ years
Body mass index	24.2±4.2	24.1±3,1	24.8±2.5	22.30±2.5	24.70±3.7	22.4±2.1	21.1±2.3
Body mass (kg)	72.2±7.5	73.1±4.5	75.4±6.5	74.7±4.5	69.8±5.5	71.2±3.5	69.2±7.5
Body height (cm)	170±4.3	172±3.3	173±4.3	169±5.3	168±2.3	169±5.3	167±6.3
Total cholesterol (mg/dL)	175±8	182±4.8	168±5.2	164±3.1	172±6.2	161+7.1	171±3.8

Table 2 Selected parameters of pro- and antioxidant balance in the blood of the examined groups (mean ± SD)

Age groups (years)	Number of subjects (male/female)	Malondialdehyde [µmol/g Hb]	Zn,Cu-superoxide dismutase [U/g Hb]	Catalase [BU/g Hb]	Glutathione peroxidase [U/g Hb]	Glutathione reductase [U/g Hb]
55–59 (control)	37 (17/20)	0.249±0.031	2578±170.8*	24.54±1.76*	14.95±3.17*	58.55±7.13
65–69	28 (13/15)	0.240±0.026	2490±220.0	24.17±2.11	13.36±2.29	59.89±12.76
70–74	29 (12/17)	0.229±0.0350	2440 ±206.2	24.37±2.46	14.10±2.39	56.51±12.71
75–79	29 (14/15)	0.235±0.0329	2520±203.3	23.10±1.86	13.18±2.57	57.87±10.69
80–84	32 (16/16)	0.239±0.036	2310±192.7	23.09±2.12	12.86±2.56	54.75±15.89
85–89	32 (12/20)	0.239±0.0327	2275±169.9	22.39±2.29	13.09±2.14	62.97±12.27
90+	34 (16/18)	0.261±0.0346	2155±156.8	20.47±1.27	11.01±1.71	58.42±18.41

Note: *Statistically significant differences between control group (55–59 years) and elderly persons, P<0.001.

Figure 1 Maloddialdehyde (MDA) concentration with the trend line showing the tendency of change with age.

Figure 2 Superoxide dismutase (SOD) activity with the trend line showing the tendency of change with age.

Figure 3 Catalase (CAT) activity with the trend line showing the tendency of change with age.

Figure 4 Glutathione peroxidase (GSH-Px) activity with the trend line showing the tendency of change with age.

Figure 5 Glutathione reductase (GR) activity with the trend line showing the tendency of change with age.

Figure 6 The correlations between the erythrocytic Zn-Cu superoxide dismutase (SOD-1) (A), catalase (CAT) (B), and glutathione peroxidase (GSH-Px) (C) activities and age of examined persons (P<0.05).