The influence of genetic factors on personality and coping with stress among healthy late reproductive age women

Figures & data

Table 1 Personality structure according to the NEO-FFI

NEO-FFI N=345	$\overline{\text{bi}x}$±SD	Min-Max	M (IQR)
Neuroticism	4.38±2.27	1–10	4 (3)
Extroversion	5.44±2.10	1–10	5 (3)
Openness to experience	6.47±1.71	1–10	7 (1)
Agreeableness	5.91±1.92	1–10	6 (2)
Conscientiousness	5.46±2.02	1–10	5 (3)

Abbreviations: N, number of participants; $\overline{\text{bi}x}$, arithmetic mean; Min, minimum value; Max, maximum value; M, median; IQR, interquartile range.

Table 2 Analysis of the relationship between personality of the participants according to the NEO-FFI and the genotype distribution of the 30-bp VNTR polymorphism in the MAO-A promoter region

NEO-FFI N=339	Genotype						Genotype relationships
	4/4 n=142		4/3 n=153		3/3 n=44		4/4 vs 4/3+3/3		3/3 vs 4/4+4/3		4/4 vs 3/3
	$\overline{\text{bi}x}$ ±SD	M (IQR)	$\overline{\text{bi}x}$±SD	M (IQR)	$\overline{\text{bi}x}$±SD	M (IQR)	Z	p	Z	p	Z	p
Neuroticism	4.50±2.26	4 (3)	4.30±2.28	4 (3)	4.29±2.22	4 (2.5)	0.90	0.37	0.40	0.69	0.66	0.51
Extroversion	5.36±2.12	5 (3)	5.50±2.20	5 (3)	5.39±1.78	5 (3)	−0.28	0.78	0.13	0.90	0.01	0.99
Openness to experience	6.48±1.75	7 (2)	6.51±1.63	7 (1)	6.41±1.78	7 (2)	−0.08	0.93	0.23	0.82	0.15	0.88
Agreeableness	5.94±1.88	6 (2)	5.98±1.77	6 (2)	5.57±2.44	6 (4)	0.10	0.92	0.69	0.49	0.57	0.57
Conscientiousness	5.32±1.95	5 (3)	5.53±2.02	5 (3)	5.61±2.25	5 (3.5)	−0.90	0.37	−0.19	0.85	−0.42	0.67

Abbreviations: N, number of participants; n, number of participants in genotypic subgroup; $\overline{\text{bi}x}$, arithmetic mean; M, median; IQR, interquartile range; Z, Mann–Whitney U test statistics; p, level of significance.

Table 3 Analysis of the relationship between personality of the participants according to the NEO-FFI and the genotype distribution of the 44-bp VNTR polymorphism in the 5-HTT (SLC 6A4) promoter region

NEO-FFI N=345	Genotype						Genotype relationships
	l/l n=132		l/s n=163		s/s n=50		l/l vs l/s + s/s		s/s vs l/l + l/s		l/l vs s/s
	$\overline{\text{bi}x}$±SD	M (IQR)	$\overline{\text{bi}x}$±SD	M (IQR)	$\overline{\text{bi}x}$±SD	M (IQR)	Z	p	Z	p	Z	p
Neuroticism	4.39±2.24	4 (3)	4.27±2.25	4 (2)	4.74±2.41	4 (4)	−0.01	0.99	−0.92	0.36	−0.75	0.45
Extroversion	5.32±1.94	5.5 (3)	5.66±2.23	5 (4)	5.04±2.05	4 (3)	−0.34	0.73	1.60	0.11	1.07	0.28
Openness to experience	6.44±1.59	7 (1.5)	6.59±1.78	7 (2)	6.20±1.81	6.5 (2)	−0.43	0.67	1.40	0.16	0.96	0.33
Agreeableness	5.95±1.88	6 (2)	6.05±1.94	6 (2)	5.32±1.86	6 (3)	0.37	0.71	2.28	0.02	1.99	0.05
Conscientious-ness	5.39±2.00	5 (3)	5.59±2.06	5 (3)	5.26±1.97	5 (3)	−0.15	0.88	0.96	0.34	0.73	0.46

Abbreviations: N, number of participants; n, number of participants in genotypic subgroup; $\overline{\text{bi}x}$, arithmetic mean; M, median; IQR, interquartile range; Z, Mann–Whitney U test statistics; p, level of significance.

Table 4 The structure of stress-coping styles adopted by the participants according to the CISS

CISS N=345	$\overline{\text{bi}x}$ ± SD	Min-Max	M (IQR)
Task-oriented coping (TOC)	5.76±1.67	1–10	5 (2)
Emotion-oriented coping (EOC)	4.73±1.85	1–10	5 (3)
Avoidance-oriented coping (AOC)	5.55±1.58	1–10	5 (1)
Engaging in alternative activities (Distraction)	5.28±1.73	1–10	5 (3)
Seeking social contact (Social Diversion)	6.07±1.80	1–10	6 (2)

Abbreviations: N, number of participants; $\overline{\text{bi}x}$, arithmetic mean; Min, minimum value; Max, maximum value; M, median; IQR, interquartile range.

Table 5 Analysis of the relationships between stress-coping styles adopted by the participants according to the CISS and the genotype distribution of the 30-bp VNTR polymorphism in the MAO promoter region

CISS N=339	Genotype						Genotype relationships
	4/4 n=142		4/3 n=153		3/3 n=44		4/4 vs 4/3+3/3		3/3 vs 4/4+4/3		4/4 vs 3/3
	$\overline{\text{bi}x}$±SD	M (IQR)	$\overline{\text{bi}x}$±SD	M (IQR)	$\overline{\text{bi}x}$ ± SD	M (IQR)	Z	p	Z	p	Z	p
Task-oriented coping (TOC)	5.72±1.69	6 (2)	5.81±1.69	5 (2)	5.79±1.70	5 (2)	0.02	0.98	0.39	0.69	0.34	0.73
Emotion-oriented coping (EOC)	4.76±1.90	5 (3)	4.65±1.82	5 (3)	4.89±1.89	4 (3)	0.40	0.69	−0.52	0.60	−0.29	0.77
Avoidance-oriented coping (AOC)	5.63±1.55	5 (2)	5,52±1.63	5 (2)	5,41±1.54	5 (1)	0.76	0.44	0.90	0.37	1.03	0.30
Engaging in alternative activities (Distraction)	5.27±1.73	5 (2)	5.27±1.75	5 (3)	5.25±1.73	5 (3)	0.21	0.83	0.06	0.95	0.10	0.92
Seeking social contact (Social Diversion)	6.22±1.66	7 (2)	5.95±1.84	6 (2)	6.00±2.04	6.5(3)	1.16	0.25	0.08	0.94	0.46	0.64

Abbreviations: N, number of participants; n, number of participants in genotypic subgroup; $\overline{\text{bi}x}$, arithmetic mean; M, median; IQR, interquartile range; Z, Mann–Whitney U test statistics; p, level of significance.

Table 6 Analysis of the relationships between stress-coping styles adopted by the participants according to the CISS and the genotype distribution of the 44-bp VNTR polymorphism in the 5-HTT (SLC 6A4) promoter region

NEO-FFI N=345	Genotype						Genotype relationships
	l/l n=132		l/s n=163		s/s n=50		l/l vs l/s + s/s		s/s vs l/l + l/s		l/l vs s/s
	$\overline{\text{bi}x}$±SD	M (IQR)	$\overline{\text{bi}x}$±SD	M (IQR)	$\overline{\text{bi}x}$±SD	M (IQR)	Z	p	Z	p	Z	p
Task-oriented coping (TOC)	5.60±1.59	5 (1.5)	5.93±1.76	5 (2)	5.66±1.73	5 (2)	−1.00	0.31	0.50	0.62	−0.02	0.98
Emotion-oriented coping (EOC)	4.86±1.91	5 (3)	4.66±1.82	5 (3)	4.58±1.83	4.5 (3)	0.73	0.47	0.54	0.59	0.72	0.47
Avoidance-oriented coping (AOC)	5.60±1.57	5 (1.5)	5.57±1.63	5 (2)	5.34±1.48	5 (1)	0.87	0.37	1.19	0.23	1.35	0.17
Engaging in alternative activities (Distraction)	5.34±1.72	5 (3)	5.28±1.77	5 (3)	5.12±1.66	5 (2)	0.55	0.58	0.99	0.32	1.01	0.31
Seeking social contact (Social Diversion)	6.11±1.72	7 (2)	6.11±1.92	6 (2)	5.80±1.62	6 (2)	0.54	0.59	1.16	0.24	1.13	0.26

Abbreviations: N, number of participants; n, number of participants in genotypic subgroup; $\overline{\text{bi}x}$, arithmetic mean; M, median; IQR, interquartile range; Z, Mann–Whitney U test statistics; p, level of significance.

Table 7 Correlations between the NEO-FFI and the CISS scales

NEO-FFI N=345	CISS scales
	Task-oriented coping (TOC)		Emotion-oriented coping (EOC)		Avoidance-oriented coping (AOC)		Engaging in alternative activities (Distraction)		Seeking social contact (Social Diversion)
	R	p	R	p	R	p	R	p	R	p
Neuroticism	−0.27	0.00	0.74	0.00	0.04	0.41	0.26	0.00	−0.31	0.00
Extroversion	0.44	0.00	−0.20	0.00	0.21	0.00	0.07	0.21	0.24	0.00
Openness to experience	0.22	0.00	−0.16	0.00	0.04	0.42	−0.08	0.12	0.24	0.00
Agreeableness	0.12	0.02	−0.42	0.00	−0.14	0.01	−0.25	0.00	0.21	0.00
Conscientiousness	0.46	0.00	−0.13	0.02	0.02	0.73	−0.02	0.63	0.00	0.96

Abbreviations: N, number of participants; R, Spearman’s rank correlation coefficient; p, level of significance.