The Serum Concentration of Anti-Aging Proteins, Sirtuin1 and αKlotho in Patients with End-Stage Kidney Disease on Maintenance Hemodialysis

Figures & data

Table 1 The Clinical Characteristics of Studied Groups (Divided According to the Presence of Residual Renal Function)

	Whole Group N=103	Presence of Residual Renal Function N=51	Absence of Residual Renal Function N=52	P
Age (years)	67 (56–77)	67.0 (57.0–76.0)	64.0 (52.0–77.0)	p>0.05
Hemodialysis vintage (months)	36 (14.9–68.1)	27.3 (12.0–48.0)	645 (36.0–114.3)	0.0003
BP before HD (mmHg)	138/74 (124/65–152/82)	137/73 (121/66–152/81)	141/74 (125/62–153/83)	p>0.05
BP after HD (mmHg)	132/68 (110/61–145/80)	126/68 (110/60–136/77)	139/68 (104/60–149/80)	p>0.05
Hypertension	N=69 (67%)	N=34 (66.7%)	N=35 (67.3%)	p>0.05
Low flux dialyser	N=90 (87.4%)	N=46 (90.2%)	N=44 (84.6%)	p>0.05
High flux dialyser	N=13 (12.6%)	N=6 (11.7%)	N=7 (13.5%)	p>0.05

Notes: Baseline characteristic of studied population. Data are presented as median and interquartile range (IQR) for continuous variables or number of cases and percentage.

Abbreviations: BP, blood pressure; HD, hemodialysis.

Table 2 Anti-Aging Proteins Concentration in the Study Group Comparing to Control Group

Protein	Study Group (N=103)	Control Group (N=21)	p
Sirtuin1 (ng/mL)	28.4 (13.5–42.8)	2.71 (1.9–5.0)	<0.0001
αKlotho (pg/mL)	433.9 (362–580)	756.6 (632.7–939.1)	<0.0001

Note: Data are presented as median and interquartile range (IQR) for continuous variables.

Table 3 Anti-Aging Proteins Concentration in the Studied Groups (Divided According to the Presence/Absence of Residual Renal Function)

Protein	Whole Group N=103	Presence of Residual Renal Function N=51	Absence of Residual Renal Function N=52	P
Sirtuin1 (ng/mL)	28.4 (13.5–42.8)	24.9 (11.6–39.3)	30.3 (14.6–46.7)	>0.05
αKlotho (pg/mL)	433.90 (362.9–580.4)	486.2 (400.8–592.6)	387.2 (314.7–596.1)	0.028

Note: Data are presented as median and interquartile range (IQR) for continuous variables.

Figure 1 Serum sirtuin1 in the study and control group.

Figure 2 Relationship between sirtuin1 and the duration of hemodialysis.

Figure 3 Relationship between αKlotho and left ventricular posterior wall thickness.