Impact of Different Geriatric Conditions on Choice of Therapy and In-Hospital Outcomes in Elderly Patients with Acute Coronary Syndrome

Figures & data

Table 1 Baseline Demographic Data

	All Patients	No Angiography	Angiography	p-Value
Age, years	81.9±5.3	83.5±6.0	80.9±4.7	0.015
Body mass index	26.8±4.1	26.1±3.6	27.2±4.5	0.188
Male gender	60 (56.6%)	18 (47.7%)	42 (61.8%)	0.152
TIA, intracranial bleeding	22 (20.8%)	10 (26.3%)	12 (17.6%)	0.291
GFR ≥60 mL/min/1.73 m^2	38 (41.3%)	15 (48.4%)	23 (37.7%)	0.527
GFR <30, ≤60 mL/min/1.73 m^2	40 (43.5%)	11 (35.5%)	29 (47.5%)
GFR ≥ 30 mL/min/1.73 m^2	14 (15.2%)	5 (16.1%)	9 (14.8%)
Prior CAD	71 (67.0%)	26 (68.8%)	45 (66.2%)	0.814
Prior PCI	48 (45.3%)	16 (42.1%)	32 (47.1%)	0.623
Prior CABG	7 (6.6%)	2 (5.3%)	5 (7.4%)	0.678
Prior MI	37 (34.9%)	12 (31.6%)	25 (36.8%)	0.591
Heart Failure NYYA
0	65 (61.3%)	23 (60.5%)	42 (61.8%)	0.612
1	37 (34.9%)	13 (34.2%)	24 (35.3%)
2	3 (2.8%)	1 (2.6%)	2 (2.9%)
3	1 (0.9%)	1 (2.6%)	0 (0.0%)
COPD	25 (23.6%)	13 (34.2%)	12 (17.6%)	0.054
Atrial fibrillation	32 (30.2%)	12 (31.6%)	20 (29.4%)	0.816
History of smoking	21 (19.8%)	9 (23.7%)	12 (17.6%)	0.455
Hypercholesteremia	69 (65.1%)	19 (50.0%)	50 (73.5%)	0.015
Diabetes	43 (40.6%)	14 (36.8%)	29 (42.6%)	0.559
Hypertension	95 (89.6%)	33 (86.8%)	62 (91.1%)	0.483
Family history of cardiovascular disease	26 (24.5%)	10 (26.3%)	16 (23.5%)	0.749
Creatinine, mg/dL	1.38±0.72	1.23±0.43	1.46±0.83	0.060
CRP, mg/dL	2.66±4.33	2.60±4.29	2.69±4.38	0.925
CRP max, mg/dL	6.25±7.90	6.75±7.97	5.97±7.91	0.630
Troponin T, ng/mL	0.25±0.64	0.18±0.41	0.29±0.72	0.402
Troponin max, ng/mL	0.39±0.74	0.24±0.49	0.47±0.85	0.089
Hb, g/dL	14.7±17.0	12.8±2.3	15.8±21.2	0.408
CK, U/L	223.7±240.0	219.7±232.5	225.9±246.5	0.901
CK max, U/L	405.5±601.0	419.2±708.0	397.6±538.5	0.860
CK MB, μg/L	31.2±26.8	33.4±30.0	30.0±25.0	0.529
CK MB max, μg/L	44.2±67.3	37.8±34.0	48.7±80.1	0.426

Table 2 Geriatric Scores According to the Type of Diagnosis and Treatment

	All Patients	No Angiography	Angiography	p-Value
Killip-score	1.24±0.49	1.37±0.63	1.16±0.37	0.400
Charlson comorbidity index	3.1±2.1	3.2±2.5	3.0±1.9	0.691
Clinical Frailty Scale	3.6±1.8	4.0±2.0	3.4±1.6	0.119
Geriatric Depression Scale	4.4±2.8	4.6±2.4	4.3±2.5	0.567
Instrumental activities of daily living (IADL)	6.0±2.6	5.4±2.7	6.3±2.5	0.087
Euro-score	7.39±2.76	7.71±3.30	7.21±2.41	0.505
Mini Mental State	25.2±5.8	24.2±6.4	25.8±5.4	0.187
Barthel index	85.9±20.5	82.2±21.4	88.0±19.9	0.180
Grace-score	145.3±22.1	149.3±23.6	143.0±21.1	0.156

Figure 1 Overview of the Geriatric Scores According to the Type of DIagnosis and Treatment.

Table 3 Predictors of Angiography According to Level of Dementia, Activities of Daily Living, Clinical Frailty Scale and Age

	All Patients n (%)	No Angiography n (%)	Angiography n (%)	p-Value
0	39 (39.4)	11 (31.4)	28 (43.8)	0.027
1	28 (28.3)	6 (17.1)	22 (34.4)
2	10 (10.1)	4 (11.4)	6 (9.4)
3	17 (17.2)	11 (31.4)	6 (9.4)
4	5 (5.1)	3 (8.6)	2 (3.1)

Notes: MMS_baseline_cat ≤2, IADL ≤ 7, CFS ≥ 4, age ≥85.

Table 4 In-Hospital Outcomes

	All Patients	No Angiography	Angiography	p-Value
Composite clinical endpoint (death, re-MI, bleeding)	9 (8.5%)	2 (5.3%)	7 (10.3%)	0.373
Death, all caused	4 (3.8%)	0 (0.0%)	4 (5.9%)	0.127
Re-MI	0 (0.0%)	0 (0.0%)	0 (0.0%)	-
Bleeding	5 (4.7%)	2 (5.3%)	3 (4.4%)	0.841
Acute renal failure	3 (2.8%)	2 (5.3%)	1 (1.5%)	0.259