Two-year Outcome of Quality of Life and Health Status for the Elderly with Chronic Limb-threatening Ischemia

Figures & data

Table 1 Baseline Characteristics

	Total n=195 (100)
Gender
Male	110 (56)
Female	85 (44)
Age
Median age (IQR)	80 (75, 84)
Rutherford class
Category 4	64 (33)
Category 5/6	131 (67)
Comorbidity
Pulmonary	108 (55)
Cardiac	134 (69)
Neurological	63 (32)
Arthritis	58 (30)
Vascular risk factors
Hypertension	130 (57)
Diabetes mellitus	94 (48)
Renal impairment	111 (57)
Currently smoking	45 (23)
Preoperative risk scores
ASA score 2	53 (27)
ASA score 3	124 (64)
ASA score 4	18 (9)
V-POSSUM score
Median morbidity (IQR)	55 (35, 73)
Median mortality (IQR)	15 (8, 25)
Primary Treatment
Surgical revascularization	67 (34)
Endovascular revascularization	82 (42)
Conservative treatment	46 (24)

Note: Data are presented as number of patients and (%), unless otherwise specified.

Figure 1 Screened and Included Patients.

Figure 2 Quality of Life. Data is presented as mean and standard deviation. *Significant difference between the treatment group and the surgical treatment group (p<0.05). **Significant difference in the treatment group between this measurement and baseline (p<0.05).

Table 2 WHOQOL-BREF Compared to Normal Values for Elderly

	n	Mean Estimate	Mean Estimate in the General Elderly Population	Mean Difference	95%CI	p-value
Baseline QoL domains
Overall			3.90
Total cohort	193	3.086		−0.815	−0.936; −0.693	<0.001
Endovascular group	81	3.105		−0.795	−0.992; −0.598	<0.001
Surgery group	67	3.045		−0.855	−1.067; −0.643	<0.001
Conservative group	45	3.111		−0.789	−1.024; −0.554	<0.001
Physical			14.869
Total cohort	192	10.903		−3.966	−4.362; −3.570	<0.001
Endovascular group	81	10.899		−3.970	−4.604; −3.337	<0.001
Surgery group	65	10.422		−4.447	−5.074; −3.819	<0.001
Conservative group	46	11.589		−3.280	−4.137; −2.422	<0.001
Psychological			14.871
Total cohort	195	14.088		−0.783	−1.129; −0.437	<0.001
Endovascular group	82	14.175		−0.696	−1.239; −0.154	0.012
Surgery group	67	13.967		−0.904	−1.498; −0.310	0.003
Conservative group	46	14.109		−0.762	−1.501; −0.023	0.43
Social relationship			15.251
Total cohort	191	15.467		0.218	−0.1498; 0.586	0.244
Endovascular group	80	15.500		0.249	−0.312; 0.810	0.380
Surgery group	65	15.426		0.174	−0.416; 0.764	0.557
Conservative group	46	15.478		0.227	−0.656; 1.109	0.006
Environment			15.573
Total cohort	188	15.479		−0.093	−0.386; 0.200	0.531
Endovascular group	79	15.443		−0.130	−0.590; 0.331	0.577
Surgery group	63	15.564		−0.009	−0.478; 0.459	0.969
Conservative group	46	15.427		−0.146	−0.816; 0.524	0.664
QoL domains at two-year follow-up
Overall			3.90
Total cohort	87	3.512		−0.388	−0.545; −0.231	<0.001
Endovascular group	28	3.375		−0.525	−0.865; −0.185	0.004
Surgery group	43	3.651		−0.249	−0.422; −0.076	0.006
Conservative group	13	3.346		−0.554	−1.038; −0.070	0.028
Physical			14.869
Total cohort	84	14.364		−0.505	1.094; 0.084	0.092
Endovascular group	28	13.704		−1.165	−2.341; 0.011	0.052
Surgery group	43	14.950		0.081	−0.698; 0.860	0.834
Conservative group	13	13.846		−1.023	−2.419; 0.374	0.137
Psychological			14.871
Total cohort	84	15.071		0.200	−0.226; 0.627	0.353
Endovascular group	28	14.810		−0.062	−0.904; 0.781	0.882
Surgery group	43	15.302		0.431	−0.144; 1.006	0.138
Conservative group	13	14.872		0.001	−1.131; 1.133	0.999
Social relationship			15.251
Total cohort	83	16.137		0.885	0.466; 1.305	<0.001
Endovascular group	28	15.405		0.153	−0.830; 1.137	0.751
Surgery group	42	16.508		1.277	0.810; 1.703	<0.001
Conservative group	13	16.513		1.261	0.437; 2.086	0.006
Environment			15.573
Total cohort	84	15.643		0.070	−0.240; 0.380	0.653
Endovascular group	28	15.571		−0.001	−0.576; 0.574	0.997
Surgery group	43	15.721		0.148	−0.286; 0.583	0.494
Conservative group	13	15.539		−0.034	−0.919; 0.851	0.934

Notes: Data presented as mean; a p-value of <0.05 represents a significant difference between the mean value of the general elderly population and the value in this cohort (indicated with bold front). The value of the general elderly population is based on reference 28.

Figure 3 Health status (SF-12). Data is presented as mean and standard deviation. *Significant difference between the treatment group and the surgical treatment group (p<0.05). **Significant difference in the treatment group between this measurement and baseline (p<0.05). ***Significant difference in the treatment group between this measurement and the 12-month measurement (p<0.05).

Table 3 HS Compared to Normal Values for Elderly

	n	Value	Value of General Elderly Population	Mean Difference	p-value	95%CI
Baseline HS domains
Physical			44.22
Total cohort	190	28.87		−15.35	<0.001	−16.596; −14.097
Endovascular group	78	28.88		−15.34	<0.001	−17.427; 13.256
Surgery group	66	27.98		−16.24	<0.001	−17.880; −14.608
Conservative group	46	30.15		−14.07	<0.001	−17.140; −10.999
Mental			47.71
Total cohort	190	37.44		−4.58	<0.001	11.863; −8.670
Endovascular group	78	36.98		−10.73	<0.001	−13.376; −8.090
Surgery group	66	36.13		−11.57	<0.001	−14.103; −9.054
Conservative group	46	40.12		−7.59	<0.001	−10.914; −4.272
HS domains at two-year follow-up
Physical			44.22
Total cohort	84	39.64		−10.27	<0.001	−6.984; 2.186
Endovascular group	28	37.39		−6.83	0.005	−11.381; −2.275
Surgery group	43	42.53		−1.69	0.287	−4.854; 1.474
Conservative group	13	34.89		−9.33	0.005	−15.345; −3.312
Mental			47.71
Total cohort	84	49.07		1.36	0.209	−0.774; 3.490
Endovascular group	28	46.78		−0.93	0.667	−5.320; 3.457
Surgery group	43	51.54		3.83	0.004	1.289; 6.376
Conservative group	13	45.81		−1.90	0.496	−7.778; 3.984

Notes: Data presented as mean; a p-value of <0.05 represents a significant difference between the mean value of the general elderly population and the value in this cohort (indicated with bold front). The value of the general elderly population is based on reference 29.

Figure 4 Quality of Life Trajectories.

Figure 5 Health Status Trajectories.