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Clinical Interventions in Aging Volume 16, 2021 - Issue
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Original Research

Molecular Biomarkers Associated with Early-Onset Symptomatic Intracranial Atherosclerosis

Yunfang Luo1 Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China
,
Fang Yu1 Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China
,
Xianjing Feng1 Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China
,
Di Liao1 Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China
,
Yuanlin Ying1 Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China
,
Xi Li1 Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-9601-5076
ORCID Icon,
Qin Huang1 Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China
,
Zeyu Liu1 Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China
,
Minping Wei1 Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China
,
Tingting Zhao1 Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China
,
Lin Zhang1 Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China
,
Ruxin Tu1 Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0003-1379-4201
ORCID Icon &
Jian Xia1 Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China;2 Clinical Research Center for Cerebrovascular Disease of Hunan Province, Central South University, Changsha, Hunan, People’s Republic of China;3 National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of ChinaCorrespondence[email protected]
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Pages 1013-1022 | Published online: 01 Jun 2021

Figures & data

Figure 1 Patient selection flowchart.

Abbreviations: sICAS, symptomatic intracranial atherosclerosis; TIA, transient ischemic attacks.
Figure 1 Patient selection flowchart.

Table 1 Baseline Characteristics of sICAS Patients

Figure 2 Different stenosis characteristics between early-onset and late-onset sICAS group (A-C).

Notes: Early-onset sICAS group defined as age ≤60 years old and late-onset sICAS group defined as age >60 years old; P-values <0.05 were considered statistically significant.
Figure 2 Different stenosis characteristics between early-onset and late-onset sICAS group (A-C).

Table 2 Comparison of Demographic, Laboratory and Clinical Features in Patients with Early and Late-Onset sICAS

Figure 3 Logistic regression analyses for factors independently associated with the early-onset sICAS.

Notes: The cut-off value for each biomarker was determined by the median. P-values <0.05 were considered statistically significant.
Figure 3 Logistic regression analyses for factors independently associated with the early-onset sICAS.

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