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Original Research

Systemic Immune-Inflammation Index Predicts 3-Month Functional Outcome in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis

, , , , , , , , , , , , , & ORCID Icon show all
Pages 877-886 | Published online: 20 May 2021

Figures & data

Figure 1 Flow chart for patients’ selection.

Figure 1 Flow chart for patients’ selection.

Table 1 Baseline Clinical Characteristics of AIS Patients and Healthy Controls

Table 2 Comparisons of Baseline Characteristics and Outcomes Between SII Groups

Figure 2 Receiver operator characteristic curves for the prediction of 3-month poor outcome using systemic immune-inflammation index (SII).

Figure 2 Receiver operator characteristic curves for the prediction of 3-month poor outcome using systemic immune-inflammation index (SII).

Figure 3 The association between SII and NIHSS. (A) A positive correlation of SII with NIHSS scores (rs = 0.305, p < 0.001). The red solid straight line was produced by linear regression while the black dotted line represented curve fitting by third order polynomial (cubic). (B) Patients with NIHSS > 10 (n = 60) had a significant increase in SII compared to those with NIHSS ≤ 10 (n = 156) (p = 0.001).

Abbreviations: SII, systemic immune-inflammation index; NIHSS, National Institute of Health stroke scale.
Figure 3 The association between SII and NIHSS. (A) A positive correlation of SII with NIHSS scores (rs = 0.305, p < 0.001). The red solid straight line was produced by linear regression while the black dotted line represented curve fitting by third order polynomial (cubic). (B) Patients with NIHSS > 10 (n = 60) had a significant increase in SII compared to those with NIHSS ≤ 10 (n = 156) (p = 0.001).

Table 3 Univariate and Multivariate Logistic Regression Analysis for 3-month Poor Outcome

Table 4 Reclassification and Discrimination Statistics for Poor Functional Outcomes by SII at 3 Months

Figure 4 mRS distribution at 3 months for high SII group vs low SII group. mRS, modified Rankin Scale; SII, systemic immune-inflammation index.

Figure 4 mRS distribution at 3 months for high SII group vs low SII group. mRS, modified Rankin Scale; SII, systemic immune-inflammation index.