Drugs Dosing in Geriatric Patients Depending on Kidney Function Estimated by MDRD and Cockroft-Gault Formulas

Figures & data

Table 1 The Cockcroft-Gault Formula for Estimating Creatinine Clearance (CrCl)^11,12

	CrCl
Male	([140-age] × weight in kg)/(serum creatinine × 72)
Female	CrCl (male) × 0.85

Table 2 Results of the Study

Results	Minimum Value	Maximum Value	Median	Range
Patients’ age	55 years	93 years	79 years
BMI value	16.28 kg/m^2	43.87 kg/ m^2	26.73 kg/ m^2
Body surface area	1.23 m^2	2.56 m^2	1.83 m^2
Creatinine concentration	0.49 mg/dl	2.26 mg/dl	0.9 mg/dl	1.97 mg/dl
eGFR	21 mL/min/1.73 m^2	131 mL/min/1.73 m^2	70 mL/min/1,73 m^2	110 mL/min/1.73 m^2
ClCr by C-G formula	19 mL/min	123.31 mL/min	62.5 mL/min	104.2 mL/min
Number of drugs used continuously	2	13	7
Number of drugs metabolized by the kidneys	0	5	2

Figure 1 The relationship between the absolute value of D (difference eGFR -eClCr) - Y axis and BMI - X axis. The red line represents the local regression.

Figure 2 The relationship between the absolute value of D (difference eGFR -eClCr) - Y axis, and body surface area - X axis. The red line represents the local regression.

Figure 3 The relationship between the value D (difference eGFR - eClCr) - Y axis, and BMI - X axis. The red line represents the local regression.

Figure 4 The relationship between the value D (difference eGFR - eClCr) - Y axis, and body surface area - X axis. The red line represents the local regression.

Figure 5 The relationship between the value D (difference eGFR - eClCr) - Y axis, and body mass - X axis. The red line represents the local regression.

Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16:31–41. doi:10.1159/0001805801244564

 PubMed Web of Science ®Google Scholar

Millar JA. The Cockroft and Gault formula for estimation of creatinine clearance: a friendly deconstruction. N Z Med J. 2012;125(1350):119–122.

 Google Scholar