Ingestion of BioCell Collagen^®, a novel hydrolyzed chicken sternal cartilage extract; enhanced blood microcirculation and reduced facial aging signs

Figures & data

Table 1 Study design

Procedure	Visit 1 week 0	Visit 2 week 6	Visit 3 week 12
Obtain informed consent	x
Evaluation of inclusion/exclusion criteria	x
Relevant medical history	x
Dispensal of investigational product	x	x
Dispensal of patient diary	x	x
Skin evaluation using visual analog scale	x	x	x
Skin evaluation with bioinstruments	x	x	x
Gather adverse event reports		x	x
Recovery of patient diary		x	x
Recovery of investigational product		x	x

Table 2 Baseline characteristics of the study subjects

Number of subjects	26
Age (years)	35–59
Mean ± sd (years)	50.65 ± 6.69
Sex
Female	26 (100%)
Ethnicity
Caucasian	15 (57.7%)
African American	6 (23.1%)
Hispanic	4 (15.4%)
Other	1 (3.8%)

Note: ± standard deviation.

Table 3 Effect of BioCell Collagen ingestion on facial skin appearance

Measurement	Week 0 (mean ± 1.00)	Week 6 (mean ± SD)	% change		Week 12 (mean ± SD)	% change		% change
			Wk 6-wk 0	P-value		Wk 12-wk 0	P-value	Wk 12-wk 6	P-value
Global lines/wrinkles	4.01 ± 1.00	4.91 ± 1.12	22.4	<0.001	3.48 ± 1.56	−13.2	0.028	−29.1	<0.001
Crow’s feet	2.88 ± 0.74	4.34 ± 0.95	50.7	<0.001	3.02 ± 1.28	4.9	0.422	−30.4	<0.001
Dryness/scaling	0.50 ± 0.51	0.38 ± 0.57	−24.0	0.416	0.12 ± 0.43	−76.0	0.002	−68.4	0.032

Abbreviation: SD, standard deviation.

Table 4 Effects of BioCell Collagen ingestion on epidermal and dermal components

Measurement	Week 0 (mean ± SD)	Week 6 (mean ± SD)	% change		Week 12 (mean ± SD)	% change
			Wk 6-wk 0	P-value		Wk 12- wk 0	P-value
Hydration	155.7 ± 44.8	147.3 ± 45.9	−5.4	0.420	168.2 ± 48.5	8.0 0.210
Hemoglobin	55.5 ± 15.0	65.3 ± 32.9	17.7	0.018	63.8 ± 39.4	15.0	0.008
Collagen	276.8 ± 128.0	294.4 ± 142.3	6.4	0.002	286.4 ± 149.6	3.5	0.134
Melanin	217.4 ± 117.9	212.6 ± 120.6	−2.2	0.169	216.7 ± 121.9	−0.3	0.868

Abbreviation: SD, standard deviation.