Sustained inflammation 1.5 years post-stroke is not associated with depression in elderly stroke survivors

Figures & data

Table 1 Patient characteristics

	n	Mean (SE) or % (n)	Median
Female
Age, years	67	82.1 (0.62)	83.07
MADRS	67	11.24 (1.06)	9
Major depressive episode	67	10.4% (n = 7)
Dysthymia	67	16.4% (n = 11)
DDNOS	67	4.4% (n = 3)
Stroke disability – mild	67	92.5% (n = 62)
Stroke disability – moderate	67	4.5% (n = 2)
Stroke disability – severe	67	3.0% (n = 2)
Previous stroke	67	10.4% (n = 7)
Previous heart disease	67	23.9% (n = 16)
CRP (mg/L)	67	2.83 (0.10)	2.57
WCC (10^9/L)	67	6.72 (0.23)	6.60
Male
Age, years	35	79.70 (0.76)	79.98
MADRS	35	10.15 (1.58)	7
Major depressive episode	35	17.1% (n = 6)
Dysthymia	35	2.9% (n = 1)
DDNOS	35	8.6% (n = 3)
Stroke disability – mild	35	85.7% (n = 30)
Stroke disability – moderate	35	14.3% (n = 5)
Stroke disability – severe	35	0% (n = 0)
Previous stroke	35	25.7% (n = 9)
Previous heart disease	35	25.7% (n = 9)
CRP (mg/L)	35	2.71 (0.14)	2.45
WCC (10^9/L)	35	6.40 (0.26)	6.20

Abbreviations: MADRS, Montgomery-Asberg Depression Rating Scale; DDNOS, depressive disorder not otherwise specified; CRP, C-reactive protein; WCC, white cell count.

Table 2 Results from hierarchical multiple regression analysis

	B	SE B	β	R^2
Step 1				0.087
Constant	5.23	0.76
Gender	−0.50	0.26	−0.18
Stroke disability	−0.62	0.27	−0.22*
Step 2				0.049
Constant	5.10	0.75
Gender	−0.58	0.26	−0.21*
Stroke disability	−0.63	0.26	−0.23*
Previous heart disease	0.61	0.29	0.20*
Previous stroke	0.37	0.37	0.10
Step 3				0.013
Constant	4.94	0.94
Gender	−0.56	0.26	−0.20*
Stroke disability	−0.66	0.26	−0.24*
Previous heart disease	0.63	0.29	0.20*
Previous stroke	0.37	0.36	0.10
CRP (mg/L)	0.19	0.16	0.12
WCC (10^9/L)	−0.05	0.07	−0.06

Notes: Nonstandardized (B), and standardized (β) regression coefficients, standard error of coefficients (SE B), and change in R² after each block of independent variables associated with depression at 1.5 years post-stroke, R² = 0.01 for step 1, and 0.00 for steps 2 and 3.

* P < 0.05.

Abbreviations: CRP, C-reactive protein; WCC, white cell count.