The Association Between Chronological Age and Dyslipidemia: A Cross-Sectional Study in Chinese Aged Population

Figures & data

Figure 1 The process of sample recruitment.

Table 1 Clinical Characteristics in 59,716 Chinese Aged Population

Parameter	Men (n=31,174)	Women (n=28,542)	Total (n=59,716)	P
Age, years	67.9±6.5	67.8±6.2	67.8±6.3	0.03
Height, cm	167.5±6.0	155.4±5.7	161.7±8.4	<0.001
BW, kg	69.7±9.9	59.4±9.0	64.7±10.7	<0.001
BMI, kg/m^2	24.8±3.1	24.6±3.4	24.7±3.2	<0.001
FBG, mmol/L	5.8±1.6	5.7±1.5	5.8±1.6	<0.001
SBP, mmHg	138.8±18.4	140.2±18.5	139.4±18.4	<0.001
DBP, mmHg	79.9±10.4	78.7±10.3	79.3±10.4	<0.001
TC, mmol/L	4.9±1.0	5.4±1.0	5.1±1.0	<0.001
TG, mmol/L*	1.36 (0.97, 1.95)	1.46 (1.07, 2.04)	1.4 (1.01, 1.99)	<0.001
ALT, U/L	22.3±17.1	21.6±19.9	22.0±18.5	<0.001
AST, U/L	23.0±11.4	24.1±13.3	23.5±12.4	<0.001
EGFR, mL/min	85.3±11.4	86.3±10.8	85.8±11.1	<0.001
History of hypertension, %	73.2	74.1	73.9	<0.001
History of dyslipidemia, %	43.1	57.6	50.0	<0.001
History of diabetes, %	24.5	20.1	22.4	<0.001

Notes: *Abnormal distribution, the data was presented as median plus interquartile range. The differences in continuous variables were compared with non-paired t-test if it was in normal distribution; or it was compared with Chi-square test. The differences in categorical variables were compared with Chi-square test.

Abbreviations: BW, body weight; BMI, body mass index; FBG, fasting blood glucose; SBP, systolic blood pressure; DBP, diastolic blood pressure; TC, total cholesterol; TG, total triglycerides; ALT, alanine aminotransferase; AST, aspartate aminotransferase; EGFR, estimated glomerular filtration rate.

Figure 2 (A) The concentration of total cholesterol across different age groups in 59,716 Chinese aged population. (B) The concentration of total triglycerides across different age groups in 59,716 Chinese aged population. Group 1, 60–64 y; Group 2, 65–69 y; Group 3, 70–74 y; Group 4, 75–79 y; Group 5, ≥80y. The differences in serum total cholesterol and total triglycerides were compared with ANOVA test.

Table 2 The Association Between Age and the Risk of Dyslipidemia in 59,716 Chinese Aged Population: Multivariate Logistic Regression Analysis

Model	Age Group					P Trend
	60–64 y	65–69 y	70–74 y	75–79 y	≥80 y
Number	22,138	17,819	10,578	5292	3709	N/A
Case of dyslipidemia	11,737	9149	5244	2449	1504	N/A
Model 1	1 (ref)	0.95 (0.91, 0.99)	0.88 (0.84, 0.92)	0.77 (0.72, 0.81)	0.63 (0.58, 0.67)	<0.001
Model 2	1 (ref)	0.93 (0.89, 0.96)	0.85 (0.81, 0.90)	0.76 (0.72, 0.81)	0.67 (0.62, 0.72)	<0.001
Model 3	1 (ref)	0.88 (0.84, 0.92)	0.77 (0.73, 0.81)	0.66 (0.61, 0.70)	0.55 (0.50, 0.59)	<0.001

Notes: Dyslipidemia was defined if total cholesterol≥5.7 mmol/L, or total triglycerides≥1.7 mmol/L, or self-reported history of dyslipidemia. Model 1: adjusting sex. Model 2: adjusting sex and further adjusting systolic blood pressure (mmHg), diastolic blood pressure (mmHg), fasting blood glucose (mmol/L), and BMI (kg/m²). Model 3: adjusting variables in model 2 and further adjusting estimated glomerular filtration rate (mL/min/1.73m²), alanine aminotransferase (IU/L), and aspartate aminotransferase (IU/L).

Table 3 The Association Between Age and the Risk of Dyslipidemia in Chinese Aged Population by Logistic Regression Model: Sensitivity Analysis

Sensitivity Analysis		Age Group					P Trend
		60–64 y	65–69 y	70–74 y	75–79 y	≥80 y
I	Number	9276	6958	4085	2090	1742	N/A
	Case of dyslipidemia	4391	3118	1792	836	596	N/A
	Multiple-adjusted model	1 (ref)	0.90 (0.84, 0.96)	0.79 (0.73, 0.86)	0.65 (0.58, 0.72)	0.52 (0.46, 0.59)	<0.001
II	Number	6512	3648	1653	715	458	N/A
	Case of dyslipidemia	2907	1519	642	254	116	N/A
	Multiple-adjusted model	1 (ref)	0.84 (0.77, 0.91)	0.70 (0.62, 0.79)	0.62 (0.52, 0.73)	0.41 (0.33, 0.52)	<0.001
III	Number	16,971	12,912	7293	3656	2613	N/A
	Case of dyslipidemia	8510	6346	3493	1604	979	N/A
	Multiple-adjusted model	1 (ref)	0.90 (0.86, 0.94)	0.82 (0.77, 0.87)	0.68 (0.63, 0.73)	0.54 (0.49, 0.59)	<0.001

Notes: Dyslipidemia was defined if total cholesterol≥5.7 mmol/L, or total triglycerides≥1.7 mmol/L, or self-reported history of dyslipidemia. Sensitivity I: excluding participants with low BMI (<18.5 kg/m², n=1293) and overweight and obesity (≥24.0 kg/m², n=34,272). Sensitivity II: excluding participants with high blood pressure (either systolic blood pressure≥130 mmHg or diastolic blood pressure≥130 mmHg, n=43,775) and participants with history of hypertension (n=2975). Sensitivity III: excluding participants with high fasting blood glucose (≥6.0 mmol/L, n=15,667) and participants with history of diabetes (n=594). Model: adjusting sex, systolic blood pressure (mmHg), diastolic blood pressure (mmHg), fasting blood glucose (mmol/L), BMI (kg/m²), estimated glomerular filtration rate (mL/min/1.73m²), alanine aminotransferase (IU/L), and aspartate aminotransferase (IU/L).