Impact of age on clinical presentation, treatment, and cancer-specific survival of patients with small-cell carcinoma of the prostate

Figures & data

Table 1 Characteristics of 259 patients with small-cell carcinoma of the prostate diagnosed between January 1973 and December 2004

Characteristics	n	Age at diagnosis		P
		<75 years	≥75 years
Ethnicity
Black	26	20	6	0.21
White	221	131	90
Other	12	7	5
Married
Yes	182	116	66	<0.0001
No	37	27	10
Widower	33	9	24
Unknown	7	6	1
Grade
Well differentiated	10	4	6	0.06
Moderately differentiated	10	9	1
Poorly differentiated	60	40	20
Undifferentiated	97	62	35
Unknown	82	43	39
SEER stage
Locoregional	75	46	29	0.99
Distant	123	74	49
Unstaged	18	11	7
Unknown	43	27	16
Prostatectomy
Yes	15	11	4	0.60
No	218	131	87
Unknown	26	16	10
Radiation
Yes	85	56	29	0.53
No	169	99	70
Unknown	5	3	2
Year of diagnosis
1973–1989	76	47	29	0.86
1990–2004	183	111	72

Abbreviation: SEER, Surveillance, Epidemiology, and End Results.

Figure 1 (A) Kaplan–Meier curve for overall survival (OS) in the entire cohort of patients with small-cell carcinoma of the prostate (SCCP) (n = 259). (B) cancer-specific survival of patients with SCCP. (C) cancer-specific survival of patients with SCCP by tumor histological grade. (D) cancer-specific survival of patients with SCCP by tumor stage. (E) cancer-specific survival of patients with SCCP by age group.

Notes: For the cancer-specific survival analyses, we excluded cases identified at autopsy or on the basis of death certificates only, and those with multiple primaries. A total of 218 patients were included in the cancer-specific survival analysis. The P value is shown for the log-rank test between variables.

Table 2 Cox proportional multivariate analysis of factors associated with cancer-specific mortality in 218 patients with small-cell carcinoma of the prostate

Characteristics	Group	HR	95% CI	P value
Age at diagnosis (years)	<75	1.00
	≥75	1.95	(1.30–2.93)	0.001
Ethnicity	White	1.00
	Black	1.11	(0.59–2.07)	0.747
	Other	1.68	(0.83–3.38)	0.147
Grade	Low	1.00
	High	7.13	(1.70–29.9)	0.007
	Unknown	6.51	(1.52–27.9)	0.012
SEER stage	Locoregional	1.00
	Distant	0.95	(0.59–1.53)	0.832
	Unstaged	0.79	(0.31–2.06)	0.634
	Unknown	0.53	(0.26–1.14)	0.066
Marital status	Yes
	No	1.12	(0.74–1.69)	0.606
	Unknown	0.87	(0.63–1.51)	0.799
Year of diagnosis	1973–1989	1.00
	1990–2004	1.89	(0.63–1.57)	0.893
Prostatectomy	Yes	1.00
	No	3.77	(1.51–9.47)	0.005
	Unknown	2.36	(0.75–7.47)	0.144
Radiation	Yes	1.00
	No	1.42	(0.93–2.51)	0.105
	Unknown	1.70	(0.32–3.63)	0.911

Abbreviations: HR, hazard ratio; CI, confidence interval; SEER, Surveillance, Epidemiology, and End results.