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Clinical Interventions in Aging Volume 19, 2024 - Issue
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REVIEW

Age-Related Macular Degeneration: A Disease of Cellular Senescence and Dysregulated Immune Homeostasis

Cunzi Li1 The Second Clinical Medical College of Jinan University (Shenzhen People’s Hospital), Shenzhen, 518020, People’s Republic of ChinaORCID Iconhttps://orcid.org/0009-0005-4817-9331View further author information
ORCID Icon,
Lan Zhou2 Department of Ophthalmology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, 518020, People’s Republic of China;3 Post-Doctoral Scientific Research Station of Basic Medicine, Jinan University, Guangzhou, 510632, People’s Republic of ChinaView further author information
,
Hongyan Sun2 Department of Ophthalmology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, 518020, People’s Republic of ChinaView further author information
&
Ming Ming Yang2 Department of Ophthalmology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, 518020, People’s Republic of ChinaCorrespondence[email protected]
View further author information
Pages 939-951 | Received 06 Feb 2024, Accepted 11 May 2024, Published online: 23 May 2024

Figures & data

Figure 1 Physiologic and Pathologic Images of the Retina. (a) Structure diagram of retinal layers and immunosuppressive mechanism in the retina; (b) Pathological changes in dry AMD: drusen formation, RPE dysfunction; (c) Pathological changes in wet AMD: CNV formation, photoreceptor/RPE/BM/CC atrophy and dysfunction.

Note: Created with BioRender.com.
Figure 1 Physiologic and Pathologic Images of the Retina. (a) Structure diagram of retinal layers and immunosuppressive mechanism in the retina; (b) Pathological changes in dry AMD: drusen formation, RPE dysfunction; (c) Pathological changes in wet AMD: CNV formation, photoreceptor/RPE/BM/CC atrophy and dysfunction.

Figure 2 Vicious Cycle. Mechanisms of interaction between cellular senescence and dysregulation of immune homeostasis in retina.

Note: Created with BioRender.com.
Figure 2 Vicious Cycle. Mechanisms of interaction between cellular senescence and dysregulation of immune homeostasis in retina.

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