Figures & data
Notes: Insulin resistance reduces the degradation of Aβ by IDE, and makes the combination of insulin and insulin receptor impaired. Under normal conditions, the insulin signaling pathway can inhibit Aβ production and tau protein phosphorylation through inhibiting the translation of β-site amyloidogenic cleavage of BACE1 and its substrate APP, and inhibiting phosphorylation of GSK-3β. In addition, the insulin signaling pathway prevents abnormal intracellular accumulation of Aβ by accelerating its trafficking from the Golgi and trans-Golgi network to the plasma membrane and increasing its extracellular secretion. However, insulin resistance and deficiency make insulin signal conduction abnormal, leading to increased production of Aβ in the brain with Alzheimer’s disease. Increased Aβ monomers gather into oligomers. Aβ oligomers cause abnormal activation of the TNF-α/JNK pathway, resulting in insulin resistance. Further, insulin and IGF-1 deficiency promote Aβ accumulation by decreasing the Aβ-binding carrier proteins. Aβ oligomers can also induce oxidative damage of the mitochondria.
Abbreviations: APP, amyloid precursor protein; Aβ, amyloid-β; IDE, insulin-degrading enzyme; BACE1, β-site amyloidogenic cleavage of precursor protein-cleaving enzyme 1; GSK-3β, glycogen synthase kinase-3β; IRs, insulin receptor substrates; TNF-α, tumor necrosis factor alpha; JNK, c-Jun N-terminal kinase; IGF-1, insulin-like growth factor 1.
Abbreviations: APP, amyloid precursor protein; Aβ, amyloid-β; IDE, insulin-degrading enzyme; BACE1, β-site amyloidogenic cleavage of precursor protein-cleaving enzyme 1; GSK-3β, glycogen synthase kinase-3β; IRs, insulin receptor substrates; TNF-α, tumor necrosis factor alpha; JNK, c-Jun N-terminal kinase; IGF-1, insulin-like growth factor 1.
Notes: The red line represents inhibition. The green line represents promotion.
Abbreviations: AD, Alzheimer’s disease; DPP-4, dipeptidyl peptidase-4; TZDs, thiazolidinediones; GLP-1R, glucagon-like peptide-1 receptor.
Abbreviations: AD, Alzheimer’s disease; DPP-4, dipeptidyl peptidase-4; TZDs, thiazolidinediones; GLP-1R, glucagon-like peptide-1 receptor.