Hyponatremia after initiation and rechallenge with trimethoprim–sulfamethoxazole in an older adult

Figures & data

Table 1 Trimethoprim–sulfamethoxazole (TMP–SMX) therapy and the corresponding laboratory values

Day(s)	Sodium (133–145 mmol/L)	Potassium (3.3–5.0 mmol/L)	BUN (6–23 mg/dL)	SCr (0.40–1.20 mg/dL)
−25	134	4.1	30 H	0.91
−20	137	4.6	40 H	0.79
−1	132 L	3.9	14	0.7
Index date 1	130 L	3.9	14	0.89
+8	121 L	4.7	24 H	1.1
+10	123 L	5.4 H	26 H	0.99
+15	134	4.0	20	0.76
+22	135	4.8	21	0.65
+32	137	4.3	20	0.75
+44	138	4.7	24 H	0.9
+59	137	4.1	20	0.76
+73	138	4.3	24 H	0.75
Index date 2 (+100 from index date 1)
+3	132 L	4.0	19	1.20
+3.5	132 L	4.1	17	1.05
+4	129 L	4.5	15	0.83
+5	134	3.9	10	0.66
+5.5	132 L	3.9	11	0.85
+6	132 L	3.2 L	11	0.75
+7	135	4.7	11	0.76
+8	137	4.6	14	0.74

Note: Index date refers to start date of trimethoprim-sulfamethoxazole prescription.

Abbreviations: BUN, blood urea nitrogen; SCr, serum creatinine; L, low; H, high.

Figure 1 Serum sodium levels.

Note: Index date refers to start date of trimethoprim-sulfamethoxazole prescription.