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Original Research

Real-world evaluation of compliance and preference in Alzheimer’s disease treatment

, , , , , , & show all
Pages 1779-1788 | Published online: 03 Nov 2015

Figures & data

Figure 1 Patient disposition.

Notes: A patient having completed visits up to visit 3 (week 24) was considered having completed the study.
Figure 1 Patient disposition.

Table 1 Patient demographics and baseline characteristics

Figure 2 Caregiver preference for oral or transdermal medication at the end of the study, by prior exposure.

Notes: *A P-value of <0.05 indicates a statistically significant difference in proportions between the two cohorts. P-value is based on a binomial test statistic to compare two proportions. The 95% CIs were calculated as exact binomial CIs. Exposed to oral and transdermal patch medication, of the 308 questionnaires, two were answered after patient switched from baseline therapy and were therefore not considered for statistical analyses. aPatients in the effectiveness set with missing caregiver preference assessment were not included in the calculations.

Abbreviation: CI, confidence interval.

Figure 2 Caregiver preference for oral or transdermal medication at the end of the study, by prior exposure.Notes: *A P-value of <0.05 indicates a statistically significant difference in proportions between the two cohorts. P-value is based on a binomial test statistic to compare two proportions. The 95% CIs were calculated as exact binomial CIs. Exposed to oral and transdermal patch medication, of the 308 questionnaires, two were answered after patient switched from baseline therapy and were therefore not considered for statistical analyses. aPatients in the effectiveness set with missing caregiver preference assessment were not included in the calculations.Abbreviation: CI, confidence interval.

Figure 3 Caregiver assessment of patient compliance to treatment at the end of the study.

Notes: *A P-value of <0.05 indicates a statistically significant difference in the mean scores between the two cohorts. P-value is based on Student’s t-test statistic to compare two means. A two-sided 95% confidence interval for the mean score for oral and transdermal monotherapy cohorts based on Student’s t-test statistic. Patient compliance rated on an 11-point scale from 0= “Never took the medication as prescribed” up to a maximum of 10= “Always took the medication as prescribed” using the Caregiver Medication Questionnaire. Patients in the effectiveness set with missing assessment of compliance were not included in the calculations. Compliance was assessed at the end of the study. The end of the study was at visit 3 (week 24).
Figure 3 Caregiver assessment of patient compliance to treatment at the end of the study.

Figure 4 First ranking reason for physician preference for patch medication at the end of the study.

Notes: Of the 89 physicians, 71 indicated preference for transdermal compared with 18 for oral monotherapy at the end of the study. Information was collected only once for each physician.
Figure 4 First ranking reason for physician preference for patch medication at the end of the study.

Figure 5 Drug regimen among patients on cholinesterase inhibitors and memantine at the end of the study.

Notes: For patients who switched therapy during the study, the last monotherapy dosing has been used.
Figure 5 Drug regimen among patients on cholinesterase inhibitors and memantine at the end of the study.