Prevalence of hypercalcemia of malignancy among pediatric cancer patients in the UK Clinical Practice Research Datalink database

Figures & data

Table 1 Age, sex, calendar year, and cancer type distribution of the pediatric cancer population with CSC value in CPRD 2003–2014 (N=483)

Characteristics	Males N=211 (%)	Females N=272 (%)	Total N=483 (%)
Age at first cancer diagnosis (years)
<2	12 (5.69)	14 (5.15)	26 (5.4)
2 – <6	36 (17.06)	23 (8.46)	59 (12.22)
6 – <12	47 (22.27)	65 (23.90)	112 (23.19)
12 – <18	116 (54.98)	170 (62.50)	286 (59.21)
Year of first cancer diagnosis
2003	21 (9.95)	40 (14.71)	61 (12.63)
2004	16 (7.58)	46 (16.91)	62 (12.84)
2005	24 (11.37)	24 (8.82)	48 (9.94)
2006	29 (13.74)	28 (10.29)	57 (11.80)
2007	22 (10.43)	28 (10.29)	50 (10.35)
2008	26 (12.32)	21 (7.72)	47 (9.73)
2009	28 (13.27)	24 (8.82)	52 (10.77)
2010	11 (5.21)	17 (6.25)	28 (5.80)
2011	11 (5.21)	19 (6.99)	30 (6.21)
2012	7 (3.32)	9 (3.31)	16 (3.31)
2013	11 (5.21)	11 (4.04)	22 (4.55)
2014	5 (2.37)	5 (1.84)	10 (2.07)
Cancer type at first diagnosis
Leukemia	43 (20.38)	49 (18.01)	92 (19.05)
Lymphoma	39 (18.48)	35 (12.87)	74 (15.32)
Brain tumors	22 (10.43)	35 (12.87)	57 (11.80)
Osteosarcoma and bone cancers	11 (5.21)	19 (6.99)	30 (6.21)
Thyroid cancers	–a	–a	18 (3.73)
Fibrous histiocytoma	–a	–a	16 (3.31)
Other cancersb	90 (42.65)	106 (38.97)	196 (40.58)

Notes:

a Not reported by sex owing to small cell sizes.

b Includes unknown site.

Abbreviations: CSC, corrected serum calcium; CPRD, Clinical Practice Research Datalink.

Table 2 Annual prevalence (%) of HCM among 483 pediatric cancer patients in the CPRD 2003–2014

Year	Number of cancer patients	Grade 1 or higher: CSC ≥10.8
		HCM cases	Prevalence (95% CI)
2003	61	0	n/a
2004	122	0	n/a
2005	170	0	n/a
2006	226	NRd	0.88a (0.11–3.16)
2007	272	0	n/a
2008	310	NRd	0.65a (0–2.31)
2009	354	NRd	0.28b (0–1.56)
2010	374	0	n/a
2011	386	0	n/a
2012	384	NRd	0.26b (0–1.44)
2013	371	NRd	0.27c (0–1.49)
2014	324	0	n/a

Notes: Patients had HCM grades

a 1=10.8≤ CSC ≤11.5,

b 2=11.5< CSC ≤12.5,

c 3=12.5< CSC ≤13.5.

d NR, not reported (owing to small cell size).

Abbreviations: HCM, hypercalcemia of malignancy; CPRD, Clinical Practice Research Datalink; CSC, corrected serum calcium; n/a, not applicable.