The right combination – treatment outcomes among HIV-positive patients initiating first-line fixed-dose antiretroviral therapy in a public sector HIV clinic in Johannesburg, South Africa

Kamban Hirasen1 Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South AfricaCorrespondence[email protected]

Denise Evans1 Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

Mhairi Maskew1 Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

Ian M Sanne1 Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa;2 Right to Care, Johannesburg, South Africa;3 Clinical HIV Research Unit, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

Kate Shearer1 Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

Caroline Govathson1 Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

Given Malete1 Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

Sheryl A Kluberg4 Department of Global Health, Boston University School of Public Health, Boston, MA, USA

Matthew P Fox1 Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa;4 Department of Global Health, Boston University School of Public Health, Boston, MA, USA;5 Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA

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The right combination – treatment outcomes among HIV-positive patients initiating first-line fixed-dose antiretroviral therapy in a public sector HIV clinic in Johannesburg, South Africa

Table 1 Multi-pill vs fixed-dose combination therapy by demographic and clinical characteristics at ART initiation

Table 2 Unadjusted and adjusted estimates of the relation between multi-pill initiation and fixed-dose combination initiation on attrition (LTFU + all-cause mortality)

Table 3 Unadjusted and adjusted estimates of the relation between multi-pill initiation and fixed-dose combination initiation on missed medical visits (≥1)

Table 4 Unadjusted and adjusted estimates of the relation between multi-pill initiation and fixed-dose combination initiation on virological suppression

Table S1 Unadjusted and adjusted estimates of the relation between multi-pill initiation and fixed-dose combination initiation on lost to follow-up

Table S2 Unadjusted and adjusted estimates of the relation between multi-pill initiation and fixed-dose combination initiation on all-cause mortality

Table S3 Unadjusted and adjusted estimates of the relation between multi-pill initiation and fixed-dose combination initiation on missed ARV visits (≥1)

Table S4 Virological suppression sensitivity analysis

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The right combination – treatment outcomes among HIV-positive patients initiating first-line fixed-dose antiretroviral therapy in a public sector HIV clinic in Johannesburg, South Africa

Figures & data

Table 1 Multi-pill vs fixed-dose combination therapy by demographic and clinical characteristics at ART initiation

Table 2 Unadjusted and adjusted estimates of the relation between multi-pill initiation and fixed-dose combination initiation on attrition (LTFU + all-cause mortality)

Table 3 Unadjusted and adjusted estimates of the relation between multi-pill initiation and fixed-dose combination initiation on missed medical visits (≥1)

Table 4 Unadjusted and adjusted estimates of the relation between multi-pill initiation and fixed-dose combination initiation on virological suppression

Table S1 Unadjusted and adjusted estimates of the relation between multi-pill initiation and fixed-dose combination initiation on lost to follow-up

Table S2 Unadjusted and adjusted estimates of the relation between multi-pill initiation and fixed-dose combination initiation on all-cause mortality

Table S3 Unadjusted and adjusted estimates of the relation between multi-pill initiation and fixed-dose combination initiation on missed ARV visits (≥1)

Table S4 Virological suppression sensitivity analysis

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