Second Primary Cancers in Melanoma Patients Critically Shorten Survival

Figures & data

Table 1 Distribution of Second Primary Cancer in Melanoma Patients Depending on Survival Time After First Melanoma Diagnosis

Age at Diagnosis (Years Old)	Gender	SPC Diagnosis	Survived at Least
			1 Year		5 Years		10 Years
			N	%	N	%	N	%
≤50	Men	No SPC	2602	96.0	1412	94.6	405	92.3
		Second Melanoma	67	2.5	47	3.2	22	5.0
		Other SPC	42	1.5	33	2.2	12	2.7
	Women	No SPC	4048	94.5	2251	93.1	733	91.7
		Second Melanoma	125	2.9	80	3.3	27	3.4
		Other SPC	110	2.6	87	3.6	39	4.9
51–70	Men	No SPC	4739	84.5	2295	80.3	609	77.1
		Second Melanoma	267	4.8	142	5.0	44	5.6
		Other SPC	601	10.7	420	14.7	137	17.3
	Women	No SPC	4495	89.3	2405	86.8	652	83.7
		Second Melanoma	170	3.4	105	3.8	36	4.6
		Other SPC	369	7.3	260	9.4	91	11.7
≥71	Men	No SPC	3263	80.3	1059	72.6	201	68.6
		Second Melanoma	233	5.7	108	7.4	21	7.2
		Other SPC	570	14.0	291	20.0	71	24.2
	Women	No SPC	3180	86.0	1245	82.0	240	76.4
		Second Melanoma	141	3.8	65	4.3	8	2.5
		Other SPC	378	10.2	208	13.7	66	21.0

Abbreviation: SPC, second primary cancer.

Figure 1 Survival probability after first melanoma diagnosis in patients without SPC, with second melanoma and with non-melanoma SPC. *Last cancer was melanoma for patients during the time with one single melanoma, and was SPC for those from the time with SPC.

Abbreviation: SPC, second primary cancer.

Figure 2 Survival probability after first melanoma diagnosis in patients without SPC and with SPC of good, moderate and poor prognosis. *Last cancer was melanoma for patients during the time with one single melanoma, and was SPC for those from the time with SPC.

Abbreviation: SPC, second primary cancer.

Table 2 Survival in Melanoma Patients Without Local and Distant Metastases (N0/M0) Depending on Second Primary Cancers of Different Prognostic Groups

SPC of Different Prognosis	No. at Risk	No. of Death	HR	95% CI		P-value
No SPC (ref)	15,436	1494	1.00	–	–	–
SPC of good prognosis	1162	207	1.59	1.35	1.87	3.12×10^−08
SPC of moderate prognosis	177	57	3.49	2.58	4.72	4.75×10^−16
SPC of poor prognosis	139	82	7.93	5.50	11.44	1.62×10^−28
Any SPC	1478	346	2.21	1.93	2.54	1.54×10^−29

Note: Model was adjusted for age at and year of diagnosis, tumor size, gender, histology classification.

Abbreviations: SPC, second primary cancer; HR, hazard ratio; CI, confidence interval.

Table 3 Survival in Melanoma Patients Depending on Metastases and Second Primary Cancers

SPC Diagnosis and Metastases	No. at Risk	No. of Death	HR	95% CI		P-value
No SPC
N0/M0 (ref)	15,436	1494	1.00	–	–	–
N+/M0	274	118	2.62	2.02	3.39	2.24×10^−13
M+	313	141	5.88	4.57	7.57	2.92×10^−43
Second melanoma
N0/M0	525	75	1.45	1.15	1.84	0.0018
N+/M0	10	5	4.28	2.37	7.71	1.34×10^−06
M+	14	10	11.61	6.82	19.74	1.49×10^−19
Other cancer
N0/M0	953	271	2.59	2.21	3.04	5.72×10^−32
N+/M0	14	4	1.27	0.38	4.21	0.6955
M+	9	7	6.82	3.21	14.48	5.73×10^−07

Notes: Model was adjusted for age at and year of diagnosis, tumor size, gender, histology classification. N+ includes N1, N2 and N3; M+ includes M1 and M2.

Abbreviations: SPC, second primary cancer; HR, hazard ratio; CI, confidence interval.