Platelet Count within the Normal Range at Hospital Admission is Associated with Mortality in Patients with Community-Acquired Pneumonia

Figures & data

Table 1 Characteristics of 12,905 Adult Patients Hospitalized for Community-Acquired Pneumonia Who Had Normal Platelet Counts at Admission, North and Central Denmark, 2016–2012

Variables	Values
Median age (Q1-Q3), years	73.2 (58.7–83.1)
Age ≥65 years, n (%)	8403 (65.1)
Men, n (%)	6593 (51.1)
Charlson Comorbidity Index score
0, n (%)	4691 (36.3)
1–2, n (%)	5035 (39.0)
>2, n (%)	3179 (24.6)
Mean platelet count at admission, × 10^9/L (standard deviation)	248 (72.5)
Hemoglobin level at admission
Normal (≥12 g/dL in women and ≥13 g/dL in men), n (%)	7984 (61.9)
Mild anemia (10–11.9 g/dL in women and 10–12.9 g/dL in men), n (%)	4205 (32.6)
Severe anemia (<10 g/dL), n (%)	701 (5.4)
Leukocyte count at admission
Normal (4–11 10^9/L), n (%)	6353 (49.3)
Leukopenia (<4 × 10^9/L), n (%)	169 (1.3)
Leukocytosis (>11 10^9/L), n (%)	6373 (49.4)
Creatinine level at admission ≥1.5 mg/dL, n (%)	1779 (13.8)
Admission to intensive care unit within the first 48 hours, n (%)	506 (3.9)
Mechanical ventilation	214 (1.7)

Table 2 Association Between Normal Platelet Counts at Acute Hospital Admission and 30-Day Mortality in Adult Patients Hospitalized for Community-Acquired Pneumonia Whose Platelet Counts Were Normal at Admission, North and Central Denmark, 2016–2012 (Cox Regression Model)

Platelet Count	Death at Day 30, n (%)	Adjusted Hazard Ratio (95% Confidence Interval)^a
By categories
151–175 × 10^9/L, n=1266	123 (9.7)	0.79 (0.63–0.99)
176–200 × 10^9/L, n=1640	189 (11.5)	0.94 (0.77–1.14)
201–225 × 10^9/L, n=1725	190 (11.0)	0.90 (0.74–1.10)
226–250 × 10^9/L, n=1769	208 (11.8)	0.95 (0.78–1.16)
251–275 × 10^9/L, n =1577	193 (12.2)	reference
276–300 × 10^9/L, n =1412	184 (13.0)	1.07 (0.88–1.31)
301–325 × 10^9/L, n =1165	158 (13.6)	1.11 (0.90–1.37)
326–350 × 10^9/L, n =989	145 (14.7)	1.21 (0.98–1.50)
351–375 × 10^9/L, n =757	122 (16.1)	1.34 (1.07–1.68)
376–400 × 10^9/L, n =605	89 (14.7)	1.21 (0.94–1.56)
As a continuous variable
150–275 × 10^9/L, for every 10 × 10^9/L decrease, n=7977	903 (11.3)	0.98 (0.96–1.00)
276–400 × 10^9/L, for every 10 × 10^9/L increase, n =4928	698 (14.2)	1.01 (0.99–1.03)

Notes: ^aAdjusted for age, sex, Charlson Comorbidity Index score, hemoglobin level, leukocyte count, and creatinine level at admission.