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Original Research

Maternal Smoking During Pregnancy and Offspring Head Growth in Comparison to Height and Weight Growth Up to 6 Years of Age: A Longitudinal Study

ORCID Icon, , ORCID Icon &
Pages 959-970 | Published online: 12 Oct 2021

Figures & data

Figure 1 Flow diagram of the study population. Perinatal data were obtained from the Finnish Medical Birth Register. Non-smokers did not smoke at all during pregnancy, quitters stopped smoking during the first trimester, and smokers continued smoking after the first trimester.

Abbreviation: ICD-10, International Classification of Diseases, 10th version.
Figure 1 Flow diagram of the study population. Perinatal data were obtained from the Finnish Medical Birth Register. Non-smokers did not smoke at all during pregnancy, quitters stopped smoking during the first trimester, and smokers continued smoking after the first trimester.

Table 1 Characteristics of the Study Population (N = 43,632) by Maternal Smoking Status

Table 2 Mean Unadjusted Standard Deviation Scores (Head Circumference, Length/Height, and Weight-for-Length/Height) by Maternal Smoking Status from Birth to 6 Years of Age

Figure 2 The mean difference in HC, length/height, and weight-for-length/height SDS from birth to 6 years of age between children of mothers who smoked during pregnancy and those of non-smoking mothers (marked as a line at zero), panels (AC), and between children of mothers who quit smoking during first trimester and those of non-smoking mothers (marked as a line at zero), panels (DF). Solid lines indicate the mean difference in (A and D) head circumference (HC), (B and E) length/height, and (C and F) weight-for-length/height. Error bars indicate 95% confidence intervals. Mean differences are derived from linear mixed models with adjustments for age at visit, maternal height, age at delivery, pre-pregnancy BMI, parity, socioeconomic status, housing (single or cohabiting), maternal hypertensive and diabetic conditions, fertility treatments (children conceived by in vitro fertilization had been excluded), twinning, and birth asphyxia.

Figure 2 The mean difference in HC, length/height, and weight-for-length/height SDS from birth to 6 years of age between children of mothers who smoked during pregnancy and those of non-smoking mothers (marked as a line at zero), panels (A–C), and between children of mothers who quit smoking during first trimester and those of non-smoking mothers (marked as a line at zero), panels (D–F). Solid lines indicate the mean difference in (A and D) head circumference (HC), (B and E) length/height, and (C and F) weight-for-length/height. Error bars indicate 95% confidence intervals. Mean differences are derived from linear mixed models with adjustments for age at visit, maternal height, age at delivery, pre-pregnancy BMI, parity, socioeconomic status, housing (single or cohabiting), maternal hypertensive and diabetic conditions, fertility treatments (children conceived by in vitro fertilization had been excluded), twinning, and birth asphyxia.

Table 3 Mean Adjusted Standard Deviation Scores for Head Circumference, Length/Height, and Weight-for-Length/Height by Maternal Smoking Status from Birth to 6 Years of Age