Trends in Incidence and Mortality of Gynecological and Breast Cancers in Poland (1980–2018)

Figures & data

Figure 1 Continued.

Figure 1 (A) Standardized incidence and mortality trends in breast, corpus uteri, and ovarian cancers, 1980–2018. (B) Standardized incidence and mortality trends in cervical, vaginal, and vulvar cancers, 1980–2018. *Statistically significant.

Abbreviations: APC, annual percentage change.

Table 1 Incidence and Mortality of Breast, Corpus Uteri (A), Ovarian, Cervical (B), and Vulvar and Vaginal (C) Cancers in Poland, 1980–2018

A. Breast, Corpus Uteri
Years	Breast Cancer						Corpus Uteri Cancer
	Incidence			Mortality			Incidence			Mortality
	n	CR	ASR	n	CR	ASR	n	CR	ASR	n	CR	ASR
1980	5154	28.3	23.0	3446	18.9	14.8	1524	8.4	6.7	702	3.9	2.8
1981	–	–	–	–	–	–	–	–	–	–	–	–
1982	5120	27.6	22.3	3641	19.6	15.0	1547	8.3	6.6	716	3.9	2.8
1983	5386	28.7	23.1	3664	19.5	14.8	1796	9.6	7.5	726	3.9	2.8
1984	–	–	–	–	–	–	–	–	–	–	–	–
1985	6147	32.3	26.1	3795	19.9	15.1	2029	10.6	8.4	714	3.7	2.6
1986	–	–	–	–	–	–	–	–	–	–	–	–
1987	–	–	–	–	–	–	–	–	–	–	–	–
1988	6513	33.6	26.8	4045	20.9	15.5	2200	11.3	8.8	758	2.9	2.7
1989	6706	34.5	27.5	4097	21.1	15.5	2166	11.1	8.5	702	3.6	2.5
1990	6649	34.0	26.8	4323	22.1	16.1	2301	11.8	9.0	763	3.9	2.6
1991	7343	37.4	29.2	4198	21.4	15.5	2626	13.4	10.1	776	4.0	2.7
1992	7671	29.0	30.0	4429	22.5	16.2	2611	13.3	10.1	781	4.0	2.6
1993	8416	42.6	32.3	4381	22.2	15.7	2858	14.5	10.9	724	3.7	2.4
1994	8458	42.8	32.3	4449	22.5	15.9	3001	15.2	11.3	762	3.9	2.5
1995	9173	46.3	35.3	4665	23.6	16.3	2980	15.0	11.3	763	3.9	2.5
1996	9681	48.8	35.9	4738	23.9	16.1	3043	15.3	11.1	845	4.2	2.7
1997	–	–	–	–	–	–	–	–	–	–	–	–
1998	–	–	–	–	–	–	–	–	–	–	–	–
1999	10,903	54.9	38.8	4553	22.9	14.8	3260	16.4	11.4	761	3.8	2.3
2000	11,853	59.7	41.8	4712	23.7	15.0	3496	17.6	12.0	808	4.1	2.4
2001	12,118	61.0	42.4	4825	24.3	15.0	3675	18.5	12.4	776	3.9	2.2
2002	12,132	61.5	42.0	4825	24.5	15.0	3796	19.3	12.6	757	3.8	2.2
2003	11,733	59.6	40.2	4942	25.1	15.0	3953	20.1	13.0	783	4.0	2.2
2004	12,049	61.2	40.7	4887	24.8	14.5	4193	21.3	13.4	794	4.0	2.2
2005	13,385	67.9	44.5	5112	26.0	14.9	4196	21.3	13.3	770	3.9	2.0
2006	13,322	67.6	44.2	5212	26.5	14.8	4376	22.2	13.7	814	4.1	2.2
2007	14,484	73.5	47.7	5255	26.7	14.6	4640	23.6	14.3	848	4.3	2.2
2008	14,576	74.0	47.2	5362	27.2	14.7	4820	24.5	14.4	952	4.8	2.4
A. Breast, Corpus Uteri
Years	Breast Cancer						Corpus Uteri Cancer
	Incidence			Mortality			Incidence			Mortality
	n	CR	ASR	n	CR	ASR	n	CR	ASR	n	CR	ASR
2009	15,752	79.8	50.4	5241	26.6	14.1	5061	25.7	15.0	969	4.9	2.4
2010	15,784	79.4	49.6	5226	26.3	13.7	5125	25.8	14.8	1042	5.2	2.5
2011	16,534	83.2	51.8	5437	27.4	14.2	5251	26.4	14.9	1085	5.5	2.5
2012	17,000	85.7	51.9	5574	28.1	14.1	5426	27.4	15.1	1162	5.9	2.7
2013	17,142	86.3	51.8	5816	29.3	14.5	5706	28.7	15.6	1243	6.3	2.8
2014	17,379	87.5	51.6	5975	30.1	14.8	5944	29.9	16.0	1280	6.4	2.7
2015	18,106	91.2	52.9	6319	31.8	14.6	6243	31.5	16.6	1690	8.5	3.3
2016	18,615	93.9	54.1	6493	32.7	14.9	6226	31.6	16.4	1600	8.1	3.2
2017	18,529	93.4	53.0	6670	33.6	15.0	5984	30.2	15.7	1761	8.9	3.4
2018	18,869	95.2	53.3	6895	34.8	14.7	6059	30.6	15.6	1781	9.0	3.2
B. Ovarian, Cervical
Years	Ovarian Cancer						Cervical Cancer
	Incidence			Mortality			Incidence			Mortality
	n	CR	ASR	n	CR	ASR	n	CR	ASR	n	CR	ASR
1980	1734	9.5	7.9	1464	8.0	6.5	3539	19.4	16.4	1997	11.0	8.7
1981	–	–	–	–	–	–	–	–	–	–	–	–
1982	1830	9.9	8.3	1397	7.5	6.0	3473	18.7	15.7	1913	10.3	8.1
1983	1856	9.9	8.1	1478	7.9	6.2	3612	19.3	16.0	1946	10.4	8.1
1984	–	–	–	–	–	–	–	–	–	–	–	–
1985	2150	11.3	9.4	1522	8.0	6.3	3843	20.2	16.8	2028	10.6	8.3
1986	–	–	–	–	–	–	–	–	–	–	–	–
1987	–	–	–	–	–	–	–	–	–	–	–	–
1988	2333	12.0	9.7	1731	8.9	6.9	3893	20.1	16.4	2063	10.6	8.1
1989	2370	12.2	9.9	1718	8.8	6.8	3764	19.4	15.6	2020	10.4	8.0
1990	2404	12.3	10.0	1747	8.9	6.8	3658	18.7	15.2	1981	10.1	7.7
1991	2680	13.7	10.9	1787	9.1	6.9	3954	20.2	16.2	2070	10.6	7.9
1992	2765	14.1	11.2	1850	9.2	6.9	3832	19.5	15.5	1997	10.1	7.6
1993	2982	15.1	12.0	1880	9.5	7.2	3903	19.8	15.5	2028	10.3	7.5
1994	2876	14.5	11.3	1794	9.1	6.6	3943	19.9	15.5	2032	10.3	7.5
1995	2993	15.1	11.8	1840	9.3	6.8	3856	19.5	15.1	1992	10.1	7.2
B. Ovarian, Cervical
Years	Ovarian Cancer						Cervical Cancer
	Incidence			Mortality			Incidence			Mortality
	n	CR	ASR	n	CR	ASR	n	CR	ASR	n	CR	ASR
1996	3220	16.2	12.2	1909	9.6	6.7	3990	19.6	15.0	2025	10.2	7.2
1997	–	–	–	–	–	–	–	–	–	–	–	–
1998	–	–	–	–	–	–	–	–	–	–	–	–
1999	3151	15.9	11.4	1959	9.9	6.7	3565	18.0	13.3	1859	9.4	6.4
2000	3157	15.9	11.2	2032	10.2	6.7	3777	19.0	13.8	1987	10.0	6.8
2001	3193	16.1	11.2	2152	10.8	6.9	3604	18.1	13.2	1826	9.2	6.0
2002	3267	16.6	11.3	2171	11.0	6.9	3610	18.3	13.2	1855	9.4	6.2
2003	3371	17.1	11.5	2271	11.5	7.1	3439	17.5	12.4	1825	9.3	6.0
2004	3264	16.6	10.9	2273	11.5	7.0	3345	17.0	11.9	1819	9.2	5.9
2005	3355	17.0	11.1	2357	12.0	7.0	3263	16.6	11.5	1796	9.1	5.7
2006	3291	16.7	10.8	2390	12.1	7.0	3226	16.4	11.3	1824	9.3	5.6
2007	3214	16.3	10.4	2485	12.6	7.2	3431	17.4	11.8	1907	9.7	5.9
2008	3280	16.6	10.6	2507	12.7	7.1	3270	16.6	11.2	1745	8.9	5.3
2009	3474	17.6	11.1	2510	12.7	7.0	3102	15.7	10.5	1748	8.9	5.3
2010	3587	18.1	11.3	2547	12.8	7.0	3078	15.5	10.3	1735	8.7	5.1
2011	3527	17.8	10.9	2558	12.9	6.9	2968	14.9	9.8	1656	8.3	4.8
2012	3544	17.9	10.8	2432	12.3	6.4	2783	14.0	8.9	1669	8.4	4.8
2013	3639	18.3	11.0	2603	13.1	6.8	2909	14.6	9.3	1669	8.4	4.6
2014	3722	18.7	11.1	2678	13.5	6.9	2807	14.1	8.8	1628	8.2	4.5
2015	3735	18.8	11.2	2768	14.0	6.9	2723	13.7	8.5	1585	8.0	4.2
2016	3717	18.7	10.9	2639	13.3	6.4	2622	13.2	8.1	1570	7.9	4.1
2017	3775	19.0	10.9	2670	13.5	6.3	2502	12.6	7.7	1609	8.1	4.2
2018	3734	18.8	10.7	2829	14.3	6.5	2360	11.9	7.1	1593	8.0	4.0
C. Vulvar and Vaginal
Years	Vulvar Cancer						Vaginal Cancer
	Incidence			Mortality			Incidence			Mortality
	n	CR	ASR	n	CR	ASR	N	CR	ASR	n	CR	ASR
1999	378	1.90	1.10	212	1.07	0.53	85	0.43	0.25	67	0.34	0.20
2000	406	2.04	1.18	195	0.98	0.49	89	0.45	0.25	66	0.33	0.17
2001	420	2.11	1.15	207	1.04	0.52	102	0.51	0.31	73	0.37	0.20
C. Vulvar and Vaginal
Years	Vulvar Cancer						Vaginal Cancer
	Incidence			Mortality			Incidence			Mortality
	n	CR	ASR	n	CR	ASR	N	CR	ASR	n	CR	ASR
2002	407	2.06	1.13	203	1.03	0.49	84	0.43	0.23	48	0.24	0.13
2003	408	2.07	1.09	213	1.08	0.50	111	0.56	0.32	61	0.31	0.15
2004	382	1.94	0.99	194	0.98	0.44	103	0.52	0.28	80	0.41	0.22
2005	406	2.06	1.05	169	0.86	0.39	95	0.48	0.26	92	0.47	0.22
2006	419	2.14	1.10	186	0.94	0.39	87	0.44	0.22	67	0.34	0.16
2007	439	2.23	1.11	280	1.42	0.62	95	0.48	0.25	81	0.41	0.16
2008	414	2.10	1.00	265	1.34	0.58	84	0.43	0.21	55	0.28	0.13
2009	436	2.21	1.03	232	1.18	0.49	85	0.43	0.24	53	0.27	0.13
2010	491	2.47	1.15	273	1.37	0.56	83	0.42	0.21	45	0.23	0.10
2011	463	2.33	1.06	270	1.36	0.54	101	0.51	0.26	44	0.22	0.09
2012	489	2.46	1.08	273	1.37	0.52	84	0.42	0.21	57	0.29	0.12
2013	490	2.47	1.06	303	1.53	0.55	136	0.68	0.32	63	0.32	0.12
2014	515	2.59	1.13	267	1.34	0.49	107	0.54	0.23	42	0.21	0.09
2015	581	2.93	1.25	315	1.59	0.57	104	0.52	0.23	65	0.33	0.12
2016	498	2.51	1.05	326	1.64	0.55	106	0.53	0.24	64	0.32	0.12
2017	539	2.72	1.09	315	1.59	0.56	106	0.53	0.27	56	0.28	0.10
2018	573	2.89	1.13	3.19	1.61	0.70	106	0.53	0.23	68	0.34	0.12

Notes: Missing data for 1981, 1985–1986, and 1997–1998. No data on vulvar and vaginal cancers before 1999 are available because of the lack of separate codes for them in the International Classification of Diseases, 9th revision.

Abbreviation: ASR – age-standardized ratio; CR – crude ratio.

Table 2 Age-Specific Incidence and Mortality of Breast, Corpus Uteri, Ovarian (A), Cervical, Vulvar, and Vaginal (B) Cancers in Poland, 1980–2018

A. Breast, Corpus Uteri, Ovarian
Age, years	Breast Cancer Trends		Corpus Uteri Cancer Trends		Ovarian Cancer Trends
	Incidence, APC (95% CI)	Mortality, APC, (95% CI)	Incidence, APC (95% CI)	Mortality, APC (95% CI)	Incidence, APC (95% CI)	Mortality, APC (95% CI)
0–4	–	–	–	–	–	–
5–9	–	–	–	–	–	–
10–14	–	–	–	–	1980–2018: −2.01* (−3.5 to −0.5)	–
15–19	–	–	–	–	1980–2018: −0.44 (−1.7 to 0.8)	–
20–24	1980–2018: −1.38* (−2.6 to −0.1)	–	–	–	1980–2018: −0.33 (−1.1 to 0.4)	1980–2018: −3.15* (−5.1 to −1.2)
25 − 29	1980−2018: 1.37* (0.8 to 2.0)	1980–2018: −2.43* (−3.8 to −1.0)	–	–	1980–2011: −0.32 (−1.2 to 0.5) 2011–2018: 6.32 (−1.0 to 14.2)	1980–2018: −3.50* (−4.8 to −2.2)
30–34	1980–1996: −0.09 (−1.3 to 1.2) 1996–2018: 2.67* (1.9 to 3.5)	1980–2018: −1.26* (−1.9 to −0.6)	1980–2018: 2.29* (0.7 to 3.8)	–	1980–2018: −0.43 (−0.9 to 0.0)	1980–1988: 6.44 (−7.3 to 22.3) 1988–2018: −3.82* (−4.8 to −2.8)
35–39	1980–2018: 1.70* (1.5 to 1.9)	1980–2010: −2.46* (−3.1 to −1.8) 2010–2018: 1.63 (−2.5 to 5.9)	1980–2018: 1.71* (1.0 to 2.4)	–	1980–2018: −0.26 (−0.7 to 0.1)	1980–2018: −2.72* (−3.2 to −2.3)
40–44	1980–1988: 4.66* (2.2 to 7.2) 1988–2018: 1.34* (1.2 to 1.5)	1980–1990: 1.44 (−1.2 to 4.1) 1990–2018: −2.20* (−2.7 to −1.7)	1980–2018: 1.47* (1.1 to 1.9)	1980–2018: −3.21* (−4.1 to −2.3)	1980–1991: 3.54* (1.9 to 5.2) 1991–2018: −1.31* (−1.7 to −0.9)	1980–1993: 1.44 (−0.6 to 3.5) 1993–2018: −3.01* (−3.7 to −2.3)
45–49	1980–1996: 4.06* (3.3 to 4.8) 1996–2018: 0.76* (0.3 to 1.2)	1980–1994: 0.57 (−0.4 to 1.6) 1994–2018: −2.16* (−2.6 to −1.7)	1980–2018: 1.35* (1.0 to 1.7)	1980–2018: −3.04* (−3.9 to −2.1)	1980–1993: 3.22* (2.3 to 4.1) 1993–2018: −0.96* (−1.3 to −0.7)	1980–1992: 0.81 (−1.0 to 2.6) 1992–2014: −1.63* (−2.3 to −0.9) 2014–1018: −8.75* (−16.2 to −0.7)
50–54	1980–1990: 1.30 (0.0 to 2.7) 1990–2000: 6.42* (4.7 to 8.1) 2000–2018: 0.63* (0.2 to 1.1)	1980–1995: 0.37 (−0.4 to 1.2) 1995–2018: 1.63* (−2.0 to −1.2)	1980–1993: 3.51* (2.5 to 4.6) 1993–2018: 0.73* (0.4 to 1.1)	1980–2008: −2.70* (−3.5 to −1.9) 2008–2018: 2.44 (−1.0 to 6.0)	1980–1995: 3.16* (2.3 to 4.0) 1995–2018: −1.02* (−1.5 to −0.6)	1980–2006: 0.21 (−0.3 to 0.8) 2006–2018: −2.21* (−3.7 to −0.7)
55–59	1980–1992: 1.58* (0.5 to 2.6) 1992–2002: 6.54* (5.0 to 8.1) 2002–2018: 0.09 (−0.5 to 0.7)	1980–2003: 0.18 (−0.2 to 0.5) 2003–2018: −1.43* (−1.9 to −0.8)	1980–2002: 2.43* (2.0 to 2.9) 2002–2018: 0.46 (−0.1 to 1.0)	1980–2006: −2.18* (−2.7 to −1.7) 2006–2018: 2.80* (1.4 to 4.3)	1980–1994: 3.30* (2.6 to 4.0) 1994–2018: −0.38* (−0.7 to −0.1)	1980–2018: −0.14 (−0.3 to 0.0)
60–64	1980–2004: 3.07* (2.7 to 3.4) 2004–2007: 13.57 (−2.1 to 31.7) 2007–2018: −0.54 (−1.5 to 0.5)	1980–2018: 0.11 (−0.1 to 0.3)	1980–2008: 3.08* (2.8 to 3.3) 2008–2018: −0.61 (−1.6 to 0.3)	1980–2001: −1.09* (−1.8 to −0.4) 2001–2018: 0.85* (0.0 to 1.7)	1980–1996: 2.40* (1.8 to 3.0) 1996–2018: −0.01 (−0.4 to 0.4)	1980–2018: 0.23* (0.0 to 0.4)
65–69	1980–2004: 3.07* (2.7 to 3.4) 2004–2011: 6.63* (4.1 to 9.3) 2011–2018: −0.04 (−1.9 to 1.9)	1980–2004: −0.13 (−0.4 to 0.1) 2004–2018: 0.86* (0.3 to 1.4)	1980–1993: 5.85* (4.5 to 7.2) 1993–2018: 2.38* (1.9 to 2.8)	1980–1996: 0.95 (0.0 to 2.0) 1996–2004: −2.67 (−7.6 to 2.5) 2004–2018: 3.97* (2.9 to 5.1)	1980–1991: 4.08* (2.3 to 5.9) 1991–2018: 0.58* (0.2 to 1.0)	1980–2018: 0.91* (0.7 to 1.2)
70–74	1980–1988: 1.02 (−1.5 to 3.6) 1988–1993: 7.63* (3.4 to 12.1) 1993–2006: 0.91* (0.1 to 1.7) 2006–2018: 3.08* (2.3 to 3.9)	1980–1983: 11.41* (3.8 to 19.5) 1983–2009: −0.07 (−0.4 to 0.3) 2009–2018: 2.30* (1.0 to 3.6)	1980–1994: 6.52* (5.7 to 7.4) 1994–2018: 3.01* (2.6 to 3.4)	1980–2007: −0.15 (−0.6 to 0.3) 2007–2018: 5.47* (3.8 to 7.2)	1980–1993: 4.29* (3.0 to 5.6) 1993–2018: 0.75* (0.3 to 1.2)	1980–2018: 1.56* (1.3 to 1.8)
75–79	1980–1995:3.74* (2.6 to 4.9) 1995–2018: 2.44* (1.9 to 3.0)	1980–1994: 2.09* (1.6 to 2.6) 1994–2011: −0.15 (−0.6 to 0.3) 2011–2018: 2.57* (1.2 to 4.0)	1980–2018: 3.99* (3.7 to 4.3)	1980–2007: −0.12 (−0.7 to 0.5) 2007–2018: 6.85* (4.7 to 9.1)	1980–1995: 4.56* (3.6 to 5.6) 1995–2018: 0.77* (0.3 to 1.3)	1980–2003: 2.81* (2.2 to 3.4) 2003–2018: 1.33* (0.4 to 2.3)
80–84	1980–2000: 3.43* (2.5 to 4.3) 2000–2007: −0.57 (−4.7 to 3.8) 2007–2018: 4.28* (2.5 to 6.1)	1980–2014: 1.12* (0.8 to 1.4) 2014–2018: 6.06 (−0.9 to 13.6)	1980–2018: 4.24* (3.8 to 4.6)	1980–2007: 0.12 (−0.6 to 0.8) 2007–2018: 8.40* (5.9 to 10.9)	1980–2002: 3.54* (2.7 to 4.3) 2002–2018: −0.05 (−1.1 to 1.0)	1980–2018: 2.72* (2.4 to 3.0)
85+	1980–1995: 3.10* (1.9 to 4.3) 1995–2018: 0.99* (0.4 to 1.6)	1980–2005: 2.76* (2.3 to 3.3) 2005–2013: −0.47 (−3.3 to 2.5) 2013–2018: 10.75* (5.5 to 16.3)	1980–1995: 4.53* (2.9 to 6.1) 1995–2004: 0.64 (−3.4 to 4.9) 2004–2018: 5.07* (3.5 to 6.7)	1980–2007: 1.02 (0.0 to 2.1) 2007–2018: 11.34* (7.5 to 15.3)	1980–1996: 5.72* (3.9 to 7.6) 1996–2018: −0.28 (−1.4 to 0.8)	1980–2018: 3.30* (2.7 to 3.9)
B Cervical, Vulvar, and Vaginal
Age, years	Cervix Cancer Trends		Vulvar Cancer Trends		Vaginal Cancer Trends
	Incidence, APC (95% CI)	Mortality, APC (95% CI)	Incidence, APC (95% CI)	Mortality, APC (95% CI)	Incidence, APC (95% CI)	Mortality, APC, (95% CI)
0–4	–	–	–	–	–	–
5–9	–	–	–	–	–	–
10–14	–	–	–	–	–	–
15–19	–	–	–	–	–	–
20–24	1980–1999: 0.35 (−4.2 to 5.1) 1999–2003: −29.66 (−60.9 to 26.4) 2003–2018: 4.45 (−0.6 to 9.8)	–	–	–	–	–
25–29	1980–2018: −2.87* (−3.4 to −2.3)	1980–2015: −6.01* (−7.1 to −5.0) 2015–2018: 30.96 (−14.0 to 99.3)	–	–	–	–
30–34	1980–2018: −2.96* (−3.4 to −2.5)	1980–1990: −1.38 (−5.7 to 3.1) 1990–2018: − 6.03* (−6.8 to –5.2)	–	–	–	–
35–39	1980–1991: 1.11 (−0.6 to 2.8) 1991–2018: −4.19* (−4.6 to −3.8)	1980–1994: −0.18 (−1.6 to 1.2) 1994–2016: −6.04* (−6.7 to –5.3) 2016–2018: 14.39 (−12.8 to 50.1)	1999–2018: −5.30* (−9.3 to −1.1)	–	–	–
40–44	1980–1992: 2.96* (2.0 to 3.9) 1992–2007: −3.7* (−4.3 to 3.1) 2007–2018: −5.63* (−6.5 to 4.8)	1980–1996: 1.40* (0.2 to 2.6) 1996–2018: −5.93* (−6.6 to −5.2)	1999–2018: −5.01* (−7.9 to −2.1)	–	–	–
45–49	1980–2000: 0.92* (0.2 to 1.7) 2000–2018: −5.57* (−6.2 to −4.9)	1980–2004: −0.58* (−1.1 to –0.0) 2004–2018: −6.10* (−7.1 to −5.1)	1999–2016: −1.42 (−3.6 to 0.8) 2016–2018: −43.12 (−69.8 to 7.0)	–	–	–
50–54	1980–2008: −0.46* (−0.9 to 0.0) 2008–2018: −6.85* (−8.5 to −5.1)	1980–2009: −0.38 (−0.8 to 0.0) 2009–2018: −6.95* (−9.0 to −4.9)	1999–2018: −1.26 (−2.8 to 0.3)	1999–2015: 2.56 (−0.8 to 6.1) 2015–2018: −32.25 (−56.4 to 5.3)	1999–2018: −3.91* (−7.2 to −0.5)	1999–2018: −4.85* (−9.5 to 0.0)
55–59	1980–1993: −2.61* (−3.5 to −1.7) 1993–2010: 0.06 (−0.6 to 0.7) 2010–2018: −6.65* (−8.3 to −5.0)	1980–2001: −2.48* (−3.1 to −1.8) 2001–2007: 3.96 (−1.1 to 9.2) 2007–2018: −4.16* (−5.6 to −2.7)	1999–2018: 0.35 (−1.6 to 2.3)	1999–2018: 2.37 (−1.0 to 5.8)	1999–2018: 1.38 (−1.9 to 4.8)	1999–2018: −2.89 (−7.8 to 2.3)
60–64	1980–2004: −2.40* (−2.8 to −2.0) 2004–2007: 5.51 (−9.1 to 22.4) 2007–2018: −2.49* (−3.5 to −1.5)	1980–2005: −2.17* (−2.7 to −1.6) 2005–2018: −0.17 (−1.4 to 1.1)	1999–2018: 1.28 (−0.1 to 2.7)	1999–2018: 0.54 (−1.5 to 2.6)	1999–2018: 0.99 (−1.6 to 3.6)	–
65–69	1980–1985: 4.72 (−1.6 to 11.4) 1985–2006: −2.99* (−3.6 to −2.4) 2006–2018: 0.04 (−1.1 to 1.2)	1980–1988: 1.60 (−2.2 to 5.6) 1988–2001: −3.93* (−5.1 to −2.7) 2001–2018: −0.52 (−1.2 to 0.2)	1999–2018: 0.30 (−0.8 to 1.4)	1999–2018: −0.29 (−2.5 to 1.9)	1999–2014: −3.18* (−5.9 to −0.4) 2014–2018: 18.29 (−4.4 to 46.4)	–
70–74	1980–1995: −0.20 (−0.9 to 0.5) 1995–2005: −4.86* (−6.3 to −3.4) 2005–2018: −0.53 (−1.3 to 0.2)	1980–1995: −0.75 (−1.7 to 0.3) 1995–2008: −4.08* (−5.5 to −2.7) 2008–2018: 0.92 (−0.7 to 2.6)	1999–2018: 0.73* (0.1 to 1.4)	1999–2018: 0.26 (−1.2 to 1.8)	1999–2018: 1.04 (−1.5 to 3.7)	1999–2018: −4.14* (−7.3 to −0.9)
75–79	1980–1994: 0.29 (−1.0 to 1.6) 1994–2018: −3.02* (−3.6 to −2.5)	1980–1999: −0.21 (−0.9 to 0.5) 1999–2002: −8.60 (−24.0 to 9.9) 2002–2018: −1.85* (−2.5 to −1.2)	1999–2018: 0.73 (−0.1 to 1.5)	1999–2018: 0.50 (−0.8 to 1.8)	1999–2018: −1.59 (−4.3 to 1.2)	1999–2018: −2.73 (−5.5 to 0.1)
80–84	1980–1999: 0.50 (−0.7 to 1.7) 1999–2018: −3.28* (−4.1 to −2.4)	1980–1999: 0.02 (−1.2 to 1.3) 1999–2018: −2.46 (−3.4 to −1.6)	1999–2018: 0.08 (−1.1 to 1.3)	1999–2018: 0.83 (−0.6 to 2.3)	1999–2018: −2.70* (−4.9 to −0.4)	1999–2018: −3.41* (−6.0 to −0.8)
85+	1980–2018: −1.23* (−2.0 to −0.4)	1980–2018: 0.46 (0.0 to 0.9)	1999–2018: 1.71* (0.6 to 2.8)	1999–2018: 2.64* (1.3 to 4.0)	1999–2018: 1.21 (−2.2 to 4.8)	1999–2018: −0.01 (−2.9 to 3.0)

Notes: *Statistically significant. Missing data for 1981, 1985–1986, and 1997–1998. No data on vulvar and vaginal cancers before 1999 are available because of the lack of separate codes for them in the International Classification of Diseases, 9th revision.

Abbreviation: APC - annual percentage change; CI - confidence interval.