High Validity of the Danish National Patient Registry for Systemic Anticancer Treatment Registration from 2009 to 2019

Figures & data

Figure 1 Grouping of drug entries into drug cycles.

Table 1 Study Population Characteristics

Category	Variable	Count	Ratio
Overall	Patients	12,155	100%
Sex	Male	5113	42%
	Female	7042	58%
Age at diagnosis	18–44	878	7%
	45–59	3617	30%
	60–74	6089	50%
	75+	1571	13%
Cancer Diagnosis	Brain	462	4%
	Lung	2621	22%
	Breast	2968	24%
	Gastro-esophageal	620	5%
	Pancreatic	573	5%
	Colorectal	2306	19%
	Ovarian	557	5%
	Endometrial	226	3%
	Prostatic	514	4%
	Urinary	284	2%
	Other	1024	7%

Table 2 PPV, Sensitivity, and F1-Score for Patients and L01 Drug Cycles per Diagnosis

Cancer Diagnosis	Type	MedOnc	DNPR	Intersection	PPV	Sensitivity	F1-Score
Overall	Patients	12,014	11,965	11,824	98.8%	98.4%	98.6%
	Drug cycles	215,293	216,074	198,888	92.0%	92.4%	92.2%
	With a 1-day margin	215,293	216,074	200,301	92.7%	93.0%	92.9%
Brain	Patients	440	419	397	94.7%	90.2%	92.4%
	Drug cycles	6671	6804	5546	81.5%	83.1%	82.3%
	With a 1-day margin	6671	6804	5610	82.5%	84.1%	83.3%
Lung	Patients	2613	2571	2563	99.7%	98.1%	98.9%
	Drug cycles	34,628	33,240	31,774	95.6%	91.8%	93.6%
	With a 1-day margin	34,628	33,240	32,066	96.5%	92.6%	94.5%
Breast	Patients	2937	2953	2922	99.0%	99.5%	99.2%
	Drug cycles	62,637	63,644	57,198	89.9%	91.3%	90.6%
	With a 1-day margin	62,637	63,644	57,582	90.5%	91.9%	91.2%
Gastro-oesophageal	Patients	619	611	610	99.8%	98.5%	99.2%
	Drug cycles	10,811	10,558	9863	93.4%	91.2%	92.3%
	With a 1-day margin	10,811	10,558	9998	94.7%	92.5%	93.6%
Pancreatic	Patients	573	565	565	100.0%	98.6%	99.3%
	Drug cycles	11,255	11,086	10,693	96.5%	95.0%	95.7%
	With a 1-day margin	11,255	11,086	10,726	96.8%	95.3%	96.0%
Colorectal	Patients	2255	2296	2245	97.8%	99.6%	98.7%
	Drug cycles	55,580	56,928	53,434	93.9%	96.1%	95.0%
	With a 1-day margin	55,580	56,928	53,688	94.3%	96.6%	95.4%
Ovarian	Patients	554	544	541	99.4%	97.7%	98.5%
	Drug cycles	11,901	12,252	10,586	86.4%	89.0%	87.7%
	With a 1-day margin	11,901	12,252	10,681	87.2%	89.7%	88.4%
Endometrial	Patients	225	222	221	99.5%	998.2%	98.8%
	Drug cycles	2800	3003	2511	83.6%	89.7%	86.5%
	With a 1-day margin	2800	3003	2527	84.1%	90.2%	87.1%
Prostatic	Patients	509	512	507	99.0%	99.6%	99.3%
	Drug cycles	3766	3861	3589	93.0%	95.3%	94.1%
	With a 1-day margin	3766	3861	3600	93.2%	95.6%	94.4%
Urinary	Patients	283	275	274	99.6%	96.8%	98.2%
	Drug cycles	3562	3541	3331	94.1%	93.5%	93.8%
	With a 1-day margin	3562	3541	3344	94.4%	93.9%	94.2%
Other	Patients	1006	997	979	98.2%	97.3%	97.8%
	Drug cycles	11,682	11,157	10,363	92.9%	88.7%	90.7%
	With a 1-day margin	11,682	11,157	10,479	93.9%	89.7%	91.8%

Notes: Patients are matched on encrypted CPR number, drug cycles on start date and ATC code. The 1-day margin is on the start date for drug cycles allowing additional matching if the start dates of unmatched drug cycles in MedOnc and the DNPR are 1 day or less from each other.

Figure 2 Positive predictive value vs sensitivity for the matching of drug cycles per cancer diagnosis. The area of the circle is proportional to the number of corresponding drug cycles. The lighter circles in the background correspond to the performances with a 1-day margin.

Figure 3 Evolution over time of the validity of the DNPR registrations for L01 drug cycles for systemic anticancer treatments. The lighter surface above each line represents the gain in performance by adding a 1-day margin.

Figure 4 Evolution over time of the validity of the DNPR registrations for bottom 9 performing L01 drugs. Only drugs with more than 500 cycles were considered. The lighter surface above each line represents the gain in performance by adding a 1-day margin.

Table 3 Matching Performances for Drug Cycles per Drug Type for Drugs with More Than 500 Cycles in MedOnc

ATC Code	Drug Name	Top 2 Diagnoses	MedOnc	DNPR	Matching	PPV	Sensitivity	F1-Score
L01BC02	Fluorouracil	Colorectal (19,508), Pancreatic (1552)	23,272	22,935	22,644	98.7%	97.3%	98.0%
L01CD01	Paclitaxel	Breast (12,263), Ovarian (2834)	19,001	17,793	17,208	96.7%	90.6%	93.5%
L01CA04	Vinorelbine	Lung (11,098), Breast (5751)	17,779	16,541	16,233	98.1%	91.3%	94.6%
L01XA02	Carboplatin	Lung (8794), Ovarian (3973)	16,099	15,956	15,446	96.8%	95.9%	96.4%
L01XX19	Irinotecan	Colorectal (10,924), Brain (1421)	14,981	15,051	14,500	96.3%	96.8%	96.6%
L01XC03	Trastuzumab	Breast (14,103), Gastro-esophageal (736)	15,094	14,491	14,011	96.7%	92.8%	94.7%
L01XC07	Bevacizumab	Colorectal (7140), Ovarian (2995)	13,924	13,703	13,209	96.4%	94.9%	95.6%
L01XA03	Oxaliplatin	Colorectal (8136), Gastro-esophageal (2826)	12,840	13,063	12,388	94.8%	96.5%	95.6%
L01BC06	Capecitabine	Colorectal (5163), Breast (2785)	11,173	12,394	10,460	84.4%	93.6%	88.8%
L01CD02	Docetaxel	Breast (5378), Prostatic (2703)	9964	9937	9581	96.4%	96.2%	96.3%
L01BC05	Gemcitabine	Pancreatic (5753), Urinary (1768)	9624	9475	9330	98.5%	96.9%	97.7%
L01DB03	Epirubicin	Breast (6925), Gastro-esophageal (1269)	8361	9951	8088	81.3%	96.7%	88.3%
L01AA01	Cyclophosphamide	Breast (6278), Lung (72)	6435	8053	6283	78.0%	97.6%	86.7%
L01XC06	Cetuximab	Colo-rectal (3058), Other (1415)	4754	4710	4483	95.2%	94.3%	94.7%
L01CB01	Etoposide	Lung (3894), Other (273)	4556	4467	4351	97.4%	95.5%	96.4%
L01XA01	Cisplatin	Other (1734), Lung (942)	3785	3652	3497	95.8%	92.4%	94.0%
L01BA04	Pemetrexed	Lung (1936), Other (266)	2244	2253	2216	98.4%	98.8%	98.6%
L01XC18	Pembrolizumab	Lung (1142), Urinary (265)	1688	1640	1623	99.0%	96.1%	97.5%
L01XC17	Nivolumab	Lung (1115), Other (420)	1616	1616	1600	99.0%	99.0%	99.0%
L01AX03	Temozolomide	Brain (2145), Other (78)	2318	1620	1495	92.3%	64.5%	75.9%
L01XX41	Eribulin	Breast (1475), Ovarian (6)	1481	1457	1408	96.6%	95.1%	95.8%
L01DB01	Doxorubicin	Ovarian (774), Endometrial (199)	1260	1246	1202	96.5%	95.4%	95.9%
L01XC13	Pertuzumab	Breast (1554), Other (6)	1560	1073	1035	96.5%	66.3%	78.6%
L01XE33	Palbociclib	Breast (1544), Endometrial (46)	1590	1109	998	90.0%	62.8%	74.0%
L01XX17	Topotecan	Lung (758), Ovarian (184)	1072	1056	979	92.7%	91.3%	92.0%
L01XC08	Panitumumab	Colo-rectal (1220), Ovarian (74)	1350	979	951	97.1%	70.4%	81.7%
L01XE03	Erlotinib	Lung (1223), Breast (87)	1334	1043	889	85.2%	66.6%	74.8%
L01XC14	Trastuzumab emtansine	Breast (746), Colo-rectal (3)	749	736	716	97.3%	95.6%	96.4%
L01CD04	Cabazitaxel	Prostatic (525), Other (3)	528	541	517	95.6%	97.9%	96.7%
L01XE07	Lapatinib	Breast (639), Colo-rectal (9)	648	391	336	85.9%	51.9%	64.7%