https://orcid.org/0000-0002-6191-2471
Figures & data
Figure 1 All selected medications meeting the cutoff criteria for one or more pulmonary outcomes. Figure 1 shows all 7 concurrent medications strongly associated (frequency of selection stability >0.5 for at least one outcome) with Emphysema (black bar), FEV1 (green bar), FEV1_pp (yellow bar) and FVC (blue bar) progression. The x-axis of Figure 1 is frequency of stability selection experiment using the Knockoff variable selection procedure. Higher frequency from the stability selection means a particular variable is more likely to be a true signal.
Abbreviations: LASSO, least absolute shrinkage and selection operator; P1, phase 1 (baseline); P2, phase 2 (5-year follow-up); Emphysema, percent of emphysema; FEV1, absolute forced expired volume in one second in millimeters; FEV1_pp, forced expiratory volume in one second in percent predicted using the Hankinson method; FVC, forced vital capacity in liters; Alpha and Beta, combined alpha and beta blockers; TCA, tricyclic and tetracyclic antidepressants; SCAI, selective cholesterol absorption inhibitors.
