Neonatal Phototherapy and Clinical Characteristics: The Danish National Patient Registry 2000–2016

Figures & data

Figure 1 Trends in the registration of neonatal phototherapy in the Danish National Patient Registry, nationwide and at selected Hospitals, during 2000–2016.

Table 1 Registration of Phototherapy According to Newborn Characteristics^a

Characteristics	Total	Children with Phototherapy
		No.	%
Total	71,781	3182	4.4
Sex
Girls	35,087	1455	4.1
Boys	36,694	1727	4.7
Gestational age (weeks)
20–27^b	459	395	86.1
28–31	817	640	78.3
32–34	1848	1023	55.4
35	1121	302	26.9
36	1856	224	12.1
37	4294	188	4.4
38	9909	166	1.7
39–45	51,337	241	0.5
Birth weight^c (gram)
<1000^d	476	421	88.4
1000–1499	629	504	80.1
1500–1999	1109	644	58.1
2000–2499	2597	654	25.2
2500–2999	8516	397	4.7
3000–3499	22,617	260	1.1
3500–3999	23,563	170	0.7
≥4000	11,644	96	0.8
Growth
SGA	6885	438	6.4
AGA	57,776	2469	4.3
LGA	6621	242	3.7
Number of children in pregnancy
Singletons	67,931	2253	3.3
Twins+	3850	929	24.1
Parity
Nulliparous	35,240	1897	5.4
Multiparous	36,082	1259	3.5
Missing	459	26	5.7
Apgar score at 5 minutes
9–10	68,327	2629	3.8
7–8	1661	226	13.6
0–6	486	98	20.2
Missing	1307	229	17.5
Major congenital malformation in the first year
No	68,807	2754	4.0
Yes	2974	428	14.4
Delivery method
Spontaneous delivery	47,707	1288	2.7
Forceps or vacuum extractor	5459	197	3.6
Caesarean section	15,122	1254	8.3
Other assistant delivery	3478	443	12.7
Birth asphyxia
No	69,994	2742	3.9
Yes	1787	440	24.6
Acidosis
No	71,117	3111	4.4
Yes	664	71	10.7
Infection
No	69,121	2485	3.6
Yes	2660	697	26.2
Sepsis
No	69,317	2545	3.7
Yes	2464	637	25.9
Disturbance of newborn brain
No	71,679	3143	4.4
Yes	102	39	38.2
Birth injury
No	71,480	3158	4.4
Yes	301	24	8.0
Syndrome of infants of mother with diabetes
No	70,469	2984	4.2
Yes	1312	198	15.1
Hypoglycemia
No	69,717	2738	3.9
Yes	2064	444	21.5
Underfeeding
No	71,343	3096	4.3
Yes	438	86	19.6
Neonatal convulsion
No	71,668	3167	4.4
Yes	113	15	13.3
Respiratory disorders
No	66,986	1642	2.5
Yes	4795	1540	32.1
Cardiovascular disorders
No	71,477	3092	4.3
Yes	304	90	29.6
Intracranial hemorrhage
No	71,460	2945	4.1
Yes	321	237	73.8
Hemolytic disease
No	71,489	2999	4.2
Yes	292	183	62.7
Type of hemolytic disease
No	71,489	2999	4.2
Rh isoimmunization	187	117	62.6
ABO isoimmunization	79	56	70.9
Others	26	10	38.5
Diagnosis of neonatal jaundice
No	67,446	763	1.1
Yes	4335	2419	55.8

Notes: ^aThe table is based on children born at Aarhus University Hospital from 1 January 2002 through 30 November 2016 (N=71,781). ^b140 children died in the first two days after birth were excluded from this category. ^cChildren with a missing value of birth weight and birth weight less than 100 grams were not included (n=499). ^d131 children died in the first two days after birth were excluded from this category.

Abbreviations: SGA, small for gestational age; AGA, appropriate for gestational age; LGA, large for gestational age.

Table 2 Proportion of Children Registered with Phototherapy According to Growth and Gestational Age (Preterm and Term)^a

Growth of Neonates	Children Born Preterm			Children Born at Term
	Total	Children Registered with Phototherapy		Total	Children Registered with Phototherapy
		No.	%		No.	%
SGA	590	318	53.9	6295	120	1.9
AGA	5001	2082	41.6	52,775	387	0.7
LGA	571	158	27.7	6050	84	1.4

Notes: ^aThe table is based on children born at Aarhus University Hospital from 1 January 2002 through 30 November 2016 (N=71,781); Children with a missing value of birth weight and birth weight less than 100 grams were not included (n=499).

Figure 2 Trends in the registration of neonatal phototherapy, according to sex.

Notes: These data include children born at Aarhus University Hospital from 1 January 2002 through 30 November 2016 (N=71,781).

Figure 3 Trends in the registration of neonatal phototherapy, according to gestational age.

Notes: These data include children born at Aarhus University Hospital from 1 January 2002 through 30 November 2016 (N=71,781). Trends for children born at gestational age 20–27 weeks are not presented, due to the limited numbers for each individual year.

Figure 4 Trends in the registration of neonatal phototherapy, according to birth weight.

Notes: These data include children born at Aarhus University Hospital from 1 January 2002 through 30 November 2016 (N=71,781). Children with a missing birth weight value and those with birth weights <100 grams were not included (N=499); children born with a birth weight <1000 grams are not presented, due to the limited numbers for each individual year. For children born with birth weights of 1000–1499 grams, data for the years 2008 and 2014 are not presented in the figure, due to the limited numbers of children with phototherapy during those two years.

Figure 5 Trends in the registration of neonatal phototherapy, according to neonate size (SGA, AGA, LGA).

Notes: These data include children born at Aarhus University Hospital from 1 January 2002 through 30 November 2016 (N=71,781). Children with a missing birth weight value and those with birth weights <100 grams were not included (N=499).

Abbreviations: SGA, small for gestational age; AGA, appropriate size for gestational age; LGA, large for gestational age

Table 3 Proportion of Children Registered with Phototherapy According to Gestational Age Among Singletons and Twins^a

Gestational Age, Weeks	Singletons			Twins+
	Total	Children Registered with Phototherapy		Total	Children Registered with Phototherapy
		No.	%		No.	%
20–27^b	244	207	84.8	154	139	90.3
28–31	505	396	78.4	282	218	77.3
32–34	1174	654	55.7	642	350	54.5
35	768	218	28.4	338	79	23.4
36	1429	187	13.1	423	36	8.5
37	3396	167	4.9	894	21	2.3
38–45	60,297	395	0.7	938	12	1.3

Notes: ^aThe table is based on children born at Aarhus University Hospital from 1 January 2002 through 30 November 2016 (N=71,781). ^bIncludes only children who survived the neonatal period.

Figure 6 Trends in the registration of neonatal phototherapy, according to the number of births in a pregnancy (singletons, twins+).

Notes: These data include children born at Aarhus University Hospital from 1 January 2002 through 30 November 2016 (N=71,781).

Figure 7 Trends in the registration of neonatal phototherapy, according to the parity of the mother.

Notes: These data include children born at Aarhus University Hospital from 1 January 2002 through 30 November 2016 (N=71,781).

Table 4 Clinical Measurement of Bilirubin in the Neonatal Period According to Phototherapy and Gestational Age^a

Gestational Age (Weeks)	Number of Children	Children with Measurement of Bilirubin^c		Measurement of Bilirubin (µmol/l) ^d
		Number	%	Mean	SD
Children without phototherapy
20–31^b	228	197	86.4	155.9	44.2
32–34	825	698	84.6	193.9	56.5
35–36	2451	1460	59.6	216.2	65
37–38	13,849	3343	24.1	217.2	75.5
39–45	51,096	4633	9.1	189.7	81.4
Total	68,449	10,331	15.1	201.9	76.8
Children with phototherapy
20–31^b	1035	1,014	98.0	166.8	42.2
32–34	1023	999	97.7	231.1	46.3
35–36	526	513	97.5	268.8	53.9
37–38	354	342	96.6	310.4	79.2
39–45	241	228	94.6	314.5	81.2
Total	3179	3096	97.4	231.1	75.8

Notes: ^aThe table is based on children born at Aarhus University Hospital from 1 January 2002 through 30 November 2016 (N=71,781). ^bAmong children with a gestational age 20–27 weeks, those (n=140) died in the first two days after birth were not included. ^cIt refers to measurement of total serum bilirubin or unconjugated bilirubin in the neonatal period. ^dIf a child had more than one time of measurement of bilirubin, the maximum was used.