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REVIEW

Efficacy and Safety of Liraglutide and Semaglutide on Weight Loss in People with Obesity or Overweight: A Systematic Review

ORCID Icon, ORCID Icon, ORCID Icon, & ORCID Icon
Pages 1463-1476 | Received 01 Oct 2022, Accepted 21 Nov 2022, Published online: 06 Dec 2022

Figures & data

Table 1 Basic Characteristics of Included Studies

Figure 1 Flow chart of the study selection process.

Figure 1 Flow chart of the study selection process.

Figure 2 Risk of bias assessment plots.

Figure 2 Risk of bias assessment plots.

Figure 3 Risk of bias summary plots.

Figure 3 Risk of bias summary plots.

Figure 4 Network plot. (A) (Weight loss), (B) (decreased HbA1c), (C) (total adverse events), (D) (serious adverse events), (E) (hypoglycemic events).

Note: Each node represents a specific intervention, the size of the nodes corresponds to the number of participants assigned to each treatment.
Figure 4 Network plot. (A) (Weight loss), (B) (decreased HbA1c), (C) (total adverse events), (D) (serious adverse events), (E) (hypoglycemic events).

Table 2 Design-by-Treatment Test

Table 3 The Inconsistency of Loop-Specific Approach for Efficacy and Safety

Table 4 Comparisons for the Weight Loss of the Four Interventions

Table 5 The SUCRA (%) Results of Network Meta of the 5 Outcome Indicators

Figure 5 Cumulative probability plots. (A) (Weight loss), (B) (decreased HbA1c), (C) (total adverse events), (D) (serious adverse events), (E) (hypoglycemic events).

Figure 5 Cumulative probability plots. (A) (Weight loss), (B) (decreased HbA1c), (C) (total adverse events), (D) (serious adverse events), (E) (hypoglycemic events).

Table 6 Comparisons for the Δ HbA1c (%) of the Three Interventions

Table 7 Comparisons for the Total Adverse Events of the Four Interventions

Table 8 Comparisons for the Serious Adverse Events of the Four Interventions

Table 9 Comparisons for the Hypoglycemic Episodes of the Four Interventions

Table 10 Comparisons for the Weight Loss of the Four Interventions After 6 High-Risk Studies Were Excluded

Figure 6 Funnel plots. (A) (Weight loss), (B) (decreased HbA1c), (C) (total adverse events), (D) (serious adverse events), (E) (hypoglycemic events).

Figure 6 Funnel plots. (A) (Weight loss), (B) (decreased HbA1c), (C) (total adverse events), (D) (serious adverse events), (E) (hypoglycemic events).