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Clinical Epidemiology Volume 15, 2023 - Issue
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ORIGINAL RESEARCH

The Mediating Role of Body Mass Index in the Association Between Age at First Childbirth and Lung Function Among Chinese Postmenopausal Women

Gaili Wang1 Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou, Henan, 450001, People’s Republic of ChinaView further author information
,
Huizi Tian2 Henan Provincial Center for Disease Control and Prevention, Zhengzhou, Henan, 450016, People’s Republic of ChinaView further author information
,
Kai Kang2 Henan Provincial Center for Disease Control and Prevention, Zhengzhou, Henan, 450016, People’s Republic of ChinaView further author information
,
Shixian Feng2 Henan Provincial Center for Disease Control and Prevention, Zhengzhou, Henan, 450016, People’s Republic of ChinaView further author information
,
Weihao Shao1 Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou, Henan, 450001, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0003-0362-6474View further author information
ORCID Icon,
Xiaorui Chen1 Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou, Henan, 450001, People’s Republic of ChinaView further author information
,
Caifang Zheng1 Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou, Henan, 450001, People’s Republic of ChinaView further author information
,
Bowen Zhang1 Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou, Henan, 450001, People’s Republic of ChinaView further author information
,
Pei Pei3 Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing, 100191, People’s Republic of ChinaView further author information
&
Weidong Zhang1 Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou, Henan, 450001, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-0314-7820View further author information
ORCID Icon show all
Pages 289-297 | Received 19 Oct 2022, Accepted 16 Feb 2023, Published online: 07 Mar 2023

Figures & data

Table 1 Characteristics of Participants According to Age at First Childbirth

Table 2 Association Between Age at First Childbirth and Lung Function

Table 3 Association Between Age at First Childbirth and Overweight/Obesity

Figure 1 Mediation effect of body mass index on the association between age at first childbirth and lung function. (A) FEV1; (B) FVC; (C) FEV1, % predicted; (D) FVC, % predicted.

Note: Mediation analysis was adjusted for age at baseline, marital status, educational level, household income, drinking, smoking, physical activity, height, age at menopause, type of menopause, parity, and oral contraceptive pill use.
Abbreviations: FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; β, beta coefficient; CI, confidence interval.
Figure 1 Mediation effect of body mass index on the association between age at first childbirth and lung function. (A) FEV1; (B) FVC; (C) FEV1, % predicted; (D) FVC, % predicted.

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