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ORIGINAL RESEARCH

Community Use of Repurposed Drugs Before and During COVID-19 Pandemic in the Netherlands: An Interrupted Time-Series Analysis

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Pages 923-937 | Received 20 Apr 2023, Accepted 27 Jul 2023, Published online: 04 Sep 2023

Figures & data

Table 1 ARIMA Model Results Summarizing the Association of the COVID-19 Pandemic and Stringency Index with Drug Dispensing in the Netherlands

Table 2 ARIMA Model Results Summarizing the Association of the COVID-19 Pandemic and Stringency Index with New Drug Dispensing in the Netherlands

Figure 1 Monthly prevalence (left-hand plots) and incidence (right-hand plots) per 1000 people of aggregated chloroquine drug class (HCQ and CQ) and ivermectin from January 2017 to December 2021 in the Netherlands. The gray vertical dashed line is the start date of the pandemic in the Netherlands. The blue solid line represents the observed data, the red solid line represents the data fitted by the ARIMA model, while the red dotted line with confidence interval (red bands) represents the predicted trend in the absence of a pandemic.

Figure 1 Monthly prevalence (left-hand plots) and incidence (right-hand plots) per 1000 people of aggregated chloroquine drug class (HCQ and CQ) and ivermectin from January 2017 to December 2021 in the Netherlands. The gray vertical dashed line is the start date of the pandemic in the Netherlands. The blue solid line represents the observed data, the red solid line represents the data fitted by the ARIMA model, while the red dotted line with confidence interval (red bands) represents the predicted trend in the absence of a pandemic.

Figure 2 Monthly prevalence (left-hand plots) and incidence (right-hand plots) per 1000 people of antihypertensive and antidiabetic drugs from January 2017 to December 2021 in the Netherlands. The gray vertical dashed line is the start date of the pandemic in the Netherlands. The blue solid line represents the observed data, the red solid line represents the data fitted by the ARIMA model, while the red dotted line with confidence interval (red bands) represents the predicted trend in the absence of a pandemic.

Figure 2 Monthly prevalence (left-hand plots) and incidence (right-hand plots) per 1000 people of antihypertensive and antidiabetic drugs from January 2017 to December 2021 in the Netherlands. The gray vertical dashed line is the start date of the pandemic in the Netherlands. The blue solid line represents the observed data, the red solid line represents the data fitted by the ARIMA model, while the red dotted line with confidence interval (red bands) represents the predicted trend in the absence of a pandemic.

Figure 3 Monthly prevalence per 1000 people of antiviral, antibacterial, corticosteroids for systemic use, and NSAID from January 2017 to December 2021 in the Netherlands. The gray vertical dashed line is the start date of the pandemic in the Netherlands. The blue solid line represents the observed data, the red solid line represents the data fitted by the ARIMA model, while the red dotted line with confidence interval (red bands) represents the predicted trend in the absence of a pandemic.

Figure 3 Monthly prevalence per 1000 people of antiviral, antibacterial, corticosteroids for systemic use, and NSAID from January 2017 to December 2021 in the Netherlands. The gray vertical dashed line is the start date of the pandemic in the Netherlands. The blue solid line represents the observed data, the red solid line represents the data fitted by the ARIMA model, while the red dotted line with confidence interval (red bands) represents the predicted trend in the absence of a pandemic.