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ORIGINAL RESEARCH

Absence of Coronary Artery Disease is a Strong Negative Predictor of Major Adverse Cardiovascular Events in Patients with Chronic Kidney Disease

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Pages 1109-1121 | Received 04 Aug 2023, Accepted 31 Oct 2023, Published online: 28 Nov 2023

Figures & data

Figure 1 Patient selection. Flowchart displaying selection of patients with chronic coronary syndrome.

Abbreviations: CAG, coronary angiography; CAD, coronary artery disease; eGFR, estimated glomerular filtration rate.
Figure 1 Patient selection. Flowchart displaying selection of patients with chronic coronary syndrome.

Table 1 Baseline Characteristics of Chronic Coronary Syndrome Patients Undergoing Coronary Angiography in Western Denmark

Table 2 Incidence Rate Ratios of Major Adverse Cardiovascular Events

Table 3 Major Adverse Cardiovascular Events Stratified by Coronary Artery Disease

Figure 2 Outcome graph displaying major adverse cardiovascular event rates and adjusted incidence rate ratios. (A) MACE for different eGFR strata without stratification for coronary artery disease. (B) MACE for different eGFR strata with stratification for coronary artery disease. (C) Adjusted IRR for different eGFR strata without stratification for coronary artery disease. (D) Adjusted IRR for different eGFR strata with stratification for coronary artery disease.

Abbreviations: eGFR, estimated glomerular filtration rate; MACE, major adverse cardiovascular events; IRR, incidence rate ratio; CAD, coronary artery disease.
Figure 2 Outcome graph displaying major adverse cardiovascular event rates and adjusted incidence rate ratios. (A) MACE for different eGFR strata without stratification for coronary artery disease. (B) MACE for different eGFR strata with stratification for coronary artery disease. (C) Adjusted IRR for different eGFR strata without stratification for coronary artery disease. (D) Adjusted IRR for different eGFR strata with stratification for coronary artery disease.

Figure 3 Cumulative incidence proportions.

Abbreviation: MACE, major adverse cardiovascular events.
Figure 3 Cumulative incidence proportions.

Table 4 Risk of Major Adverse Cardiovascular Events for Patients Compared to a Matched General Population

Figure 4 Cumulative incidence proportions for different kidney function strata. Patients with and without CAD on coronary angiography compared to their respective age- and sex-matched general population (GP). (A) Patients with eGFR 3 90 mL/min/1.73 m2 with or without CAD and their corresponding matched GPs. (B) Patients with eGFR 60–89 mL/min/1.73 m2 with or without CAD and their corresponding matched GPs. (C) Patients with eGFR 30–59 mL/min/1.73 m2 with or without CAD and their corresponding matched GPs. (D) Patients with eGFR <30 mL/min/1.73 m2 with or without CAD and their corresponding matched GPs.

Abbreviations: MACE, major adverse cardiovascular events; eGFR, estimated glomerular filtration rate; CAD, coronary artery disease.
Figure 4 Cumulative incidence proportions for different kidney function strata. Patients with and without CAD on coronary angiography compared to their respective age- and sex-matched general population (GP). (A) Patients with eGFR 3 90 mL/min/1.73 m2 with or without CAD and their corresponding matched GPs. (B) Patients with eGFR 60–89 mL/min/1.73 m2 with or without CAD and their corresponding matched GPs. (C) Patients with eGFR 30–59 mL/min/1.73 m2 with or without CAD and their corresponding matched GPs. (D) Patients with eGFR <30 mL/min/1.73 m2 with or without CAD and their corresponding matched GPs.