Socioeconomic status in HCV infected patients – risk and prognosis

Figures & data

Table 1 Characteristics of the 3016 hepatitis C virus (HCV) infected patients and the 15,080 controls

	HCV infected patients		Controls
	Number	Percent of total	Number	Percent of total
Total	3016	100	15,080	100
Male	1991	66.0	9955	66.0
Income in percent of national average*
0%–49%	1512	50.1	1774	11.7
50%–74%	755	25.0	3017	20.0
>75%	749	24.8	10,289	68.2
Employment
Employed	939	31.1	12,659	83.9
Unemployed/seeking education	691	22.9	1231	8.2
Disability pensioner	1386	46.0	1190	7.9
Education
Basic schooling (sixth grade)	1830	60.7	4396	29.2
Higher education	1186	39.3	10,684	70.8
Comorbidity
None (score = 0)	2248	74.5	13,335	88.4
Medium (score = 1–2)	554	18.4	1521	10.1
High (score ≥2)	214	7.1	224	1.5
Substance abuse
No	1348	44.7	14,718	97.6
Yes	1668	55.3	362	2.4
Alcohol abuse	220	7.3	261	1.7
Drug abuse	1135	37.6	66	0.4
Drug and alcohol abuse	313	10.4	35	0.2

Note:

* For same sex and age (in 5-year categories).

Figure 1 Odds ratios for being diagnosed with hepatitis C virus according to employment, income, and educational level.

Note: Odds ratios for each variable are adjusted for the other variables in the figure.
Abbreviations: CCI, Charlson Comorbidity Index; CI, confidence intervals; OR, odds ratio.

Figure 2 The association between socioeconomic status and survival in hepatitis C virus infected patients.

Note: Associations are expressed as mortality rate ratios, with associated 95% confidence intervals. Mortality rate ratios for each variable are adjusted for the other variables in the figure.
Abbreviations: CCI, Charlson Comorbidity Index; CI, confidence intervals; MMR, mortality rate ratio.

Figure 3 Survival with respect to time (years) after hepatitis C virus diagnosis according to employment and income (the year before diagnosis). The five columns indicate the number of patients at risk in each patient category to the following time points: 0 years, 2 years, 4 years, 6 years and 8 years since study inclusion.

Abbreviation: CI, confidence intervals.

Table S1 Coding algorithm used for comorbid conditions in the Charlson Comorbidity Index

Comorbid condition in CCI	ICD-8	ICD-10	Score
Myocardial infarction	410	I21, 122, I23	1
Congestive heart failure	427.09, 427.10, 427.11, 427.19, 428.99, 782.49	I50, I11.0, I13.0, I13.2	1
Peripheral vascular disease	440–445	I70–I74, I77	1
Cerebrovascular disease	430–438	I60–I69, G45, G46	1
Dementia	290.09–290.19, 293.09	F00–F03, F05.1, G30	1
Chronic pulmonary disease	490–493, 515–518	J40–J47, J60–J67, J68.4, J70.1, J70.3, J84.1, J92.0, J96.1, J98.2, J98.3	1
Connective tissue disease	712, 716, 734, 446, 139.99	M05, M06, M08, M09, M30–M36, D86	1
Ulcer disease	530.91, 530.98, 531–534	K22.1, K25–K28	1
Diabetes mellitus type 1 and 2	249.00, 249.06, 249.07, 249.09, 250.00, 250.06, 250.07, 250.09	E10.0, E10.1, E10.9, E11.0, E11.1, E11.9	1
Hemiplegia	344	G81, G82	2
Moderate to severe renal disease	403, 404, 580–584, 590.09, 593.19, 753.10–753.19, 792	I12, I13, N00–N05, N07, N11, N14, N17–N19, Q61	2
Diabetes mellitus type 1 and 2 with end organ damage	249.01–249.05, 249.08, 250.01–250.05, 250.08	E10.2–E10.8, E11.2–E11.8	2
Any tumor	140–194	C00–C75	2
Leukemia	204–207	C91–C95	2
Lymphoma	200–203	C81–C85, C88, C90, C96	2
Metastatic solid tumor	195–199	C76–C80	6
AIDS	79.83	B21–B24	6
Mild liver disease*	571, 573.01, 573.04	B18, K70.0–K70.3, K70.9, K71, K73, K74, K76.0	1
Moderate to severe liver disease*	70.00, 70.02, 70.04, 70.06, 70.08, 573.00, 456	B15.0, B16.0, B16.2, B19.0, K70.4, K72, K76.6, I85	3

Note:

* The liver diseases of the CCI were not included in our comorbidity score, as they were considered as being part of the causal pathway of mortality.

Abbreviations: CCI, Charlson Comorbidity Index; ICD, International Classification of Diseases.