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Clinical Epidemiology Volume 7, 2015 - Issue
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Methodology

The optimal hormonal replacement modality selection for multiple organ procurement from brain-dead organ donors

Zhibao Mi1 Cooperative Studies Program Coordinating Center, VA Maryland Health Care Systems, Perry Point, MD, USACorrespondence[email protected]
,
Dimitri Novitzky2 Department of Cardiothoracic Surgery, University of South Florida, Tampa, FL, USA
,
Joseph F Collins1 Cooperative Studies Program Coordinating Center, VA Maryland Health Care Systems, Perry Point, MD, USA
&
David KC Cooper3 Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA
Pages 17-27 | Published online: 22 Dec 2014

Figures & data

Table 1 Hormonal replacement modalities

Table 2 Organ transplantation rates

Figure 1 Predicted margins of the logits or LS-means estimated from each logistic regression model based on the successful procurement/transplantation rates for each organ across hormonal replacement regimen groups.

Abbreviation: LS, least square.
Figure 1 Predicted margins of the logits or LS-means estimated from each logistic regression model based on the successful procurement/transplantation rates for each organ across hormonal replacement regimen groups.

Figure 2 Dunnett’s MCC simultaneous confidence intervals for the differences of the LS-means estimated from each logistic regression model using multiple comparisons with the highest LS-mean across hormonal replacement regimen groups.

Abbreviations: LS, least square; MCC, multiple comparisons with control; UDL, upper decision limit; LDL, lower decision limit.
Figure 2 Dunnett’s MCC simultaneous confidence intervals for the differences of the LS-means estimated from each logistic regression model using multiple comparisons with the highest LS-mean across hormonal replacement regimen groups.

Figure 3 Hsu’s MCB simultaneous CIs for the differences of the LS-means estimated from each logistic regression model using multiple comparisons with the best LS-mean across hormonal replacement regimen groups.

Abbreviations: CI, confidence interval; LS, least square; MCB, multiple comparisons with the best.
Figure 3 Hsu’s MCB simultaneous CIs for the differences of the LS-means estimated from each logistic regression model using multiple comparisons with the best LS-mean across hormonal replacement regimen groups.

Figure 4 Pair-wise confidence intervals from generalized linear mixed models with four different covariance structures using the Tukey–Kramer procedure across hormonal replacement regimen groups.

Abbreviations: AR, autoregressive; CS, compound symmetry; UN, unstructured; VC, variance component.
Figure 4 Pair-wise confidence intervals from generalized linear mixed models with four different covariance structures using the Tukey–Kramer procedure across hormonal replacement regimen groups.

Table 3 LS-means estimated from different covariance structure models

Figure 5 Simultaneous confidence intervals for the differences of the LS-means estimated from generalized linear mixed models with four different covariance structures using the Dunnett–Hsu procedure across hormonal replacement regimen groups.

Abbreviations: AR, autoregressive; CS, compound symmetry; LDL, lower decision limit; LS, least square; UDL, upper decision limit; UN, unstructured; VC, variance component.
Figure 5 Simultaneous confidence intervals for the differences of the LS-means estimated from generalized linear mixed models with four different covariance structures using the Dunnett–Hsu procedure across hormonal replacement regimen groups.

Figure 6 LS-means and the simultaneous confidence intervals for the differences from generalized linear model based on the average number of organs procured from each donor using the Dunnett–Hsu MCC procedure (upper panels) and the Hsu MCB procedure (lower panels) across hormonal replacement regimen groups.

Note: The right panels were based on the models adjusted for age, sex, and BMI.
Abbreviations: BMI, body mass index; CI, confidence interval; LDL, lower decision limit; LS, least square; MCB, multiple comparisons with the best; MCC, multiple comparisons with control; NumOrg, number of organs; UDL, upper decision limit.
Figure 6 LS-means and the simultaneous confidence intervals for the differences from generalized linear model based on the average number of organs procured from each donor using the Dunnett–Hsu MCC procedure (upper panels) and the Hsu MCB procedure (lower panels) across hormonal replacement regimen groups.

Table 4 Optimal hormonal replacement modalities to maximize organ transplantation

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