The Danish Sarcoma Database

Figures & data

Figure 1 The amount of patients registered in the Danish Sarcoma Database every year since the start of the database.

Note: The increase in the amount of patients from the first 5 years to 2014 is mainly due to a more complete registration of extraskeletal sarcomas.

Figure 2 The relative distribution of patients related to age.

Table 1 The mean age for each year included in the sarcoma database

Year	Number of patients	Age (mean, years)	Lower quartile	Upper quartile	Quartile range
2009	298	54.0	39.3	68.0	28.7
2010	309	53.9	40.2	68.4	28.3
2011	305	56.3	44.5	69.7	25.2
2012	294	54.3	43.7	68.3	24.5
2013	342	55.8	43.7	69.9	26.2
2014	412	56.2	43.6	70.9	27.4

Figure 3 The distribution of malignancy grade among sarcomas registered in the Danish Sarcoma Database.

Table 2 Variables of the sarcoma database

Variable	Description
Basic data	Age, sex
	Dates: 1. first symptoms, 2. referral, 3. treatment of tumor before referral, 4. first visit at sarcoma center Intention of treatment: curative or palliative ICD-10 codes, TNM classification
Comorbidity	Charlson comorbidity score
Imaging procedures	Tumor and other locations: X-ray, MRI, CT, ultrasound, PET-CT, bone scan, and others
Tumor characteristics	Size Localization: anatomical  Soft tissue: subcutaneous, deep seated  Bone: for long bones (diaphysis, metaphysis, epiphysis)  Extension: intraosseous, cortical, extraosseous Metastasis: local, distant
Primary surgery	Date
	Type of surgery: local resection, amputation Supplementary procedures: prosthesis, tissue grafting, flap surgery, rotational plastic, cement, bone substitute, bone bridging, bone transport, arthrodesis, prosthetic mesh repair Surgical margin (surgeon’s evaluation): radical, intralesional (with or without macroscopical contamination of tissue outside tumor)
Oncological treatment	Date
	Radiation therapy (type, dose, number of fractions), chemotherapy (type, duration, ILP)
Recurrence	Date
	Local, metastasis
	Type of treatment
Pathology	Histopathological diagnosis including WHO M-code
	Grade of malignancy (FNCLCC system)
	Surgical margin (pathologist’s evaluation)
	Smallest distance from tumor to resection surface
	Growth pattern
	Vascular ingrowth
	Necrosis after chemotherapy
Complications	Postoperatively: early (<1 month postoperatively), late
	Post radiation
	Post chemotherapy
Follow-up	Date for every follow-up
	MSTS score (3 months, 1 year, 5 years)
Death	Date
	Reason (tumor, complication of treatment, others)

Abbreviations: ICD, International Classification of Diseases; TNM, tumor–node–metastasis; MRI, magnetic resonance imaging; CT, computed tomography; PET, positron emission tomography; ILP, isolated limb perfusion; WHO, World Health Organization; MSTS, Musculoskeletal Tumor Society; FNCLCC, Fédération Nationale des Centres de Lutte Contre le Cancer.

Table 3 Quality indicators with standards

Indicator		Standard
1.	Proportion of patients with subfascial tumor where MRI or CT of tumor has been performed	>95%
2.	Proportion of patients with intermediate or high-grade malignancy where chest CT or PET-CT has been performed	>95%
3.	Proportion of patients with intermediate or high-grade malignancy bone tumor where bone scan or PET-CT has been performed	>95%
4.	Proportion of patients operated with insufficient surgical margin at primary surgery	<10%
5.	Proportion of patients admitted to postoperative radiation therapy who start therapy within 60 days after surgery	>80%
6.	Proportion of patients seen at the first clinical follow-up within 6 months after the end of treatment	>90%
7.	Proportion of patients having a local recurrence within 5 years after the end of treatment	<20%
8.	Proportion of patients having a metastasis within 5 years	<30%

Abbreviations: MRI, magnetic resonance imaging; CT, computed tomography; PET, positron emission tomography.