Incidental thyroid carcinoma in surgery-treated hyperthyroid patients with Graves’ disease: a systematic review and meta-analysis of cohort studies

Figures & data

Table 1 Baseline characteristics of included studies

Study	Country	Study center	Recruiting window	Control disease	ITC number (%)	Age (years)	Female (%)	NOS
Dobyns et al,^Citation27 1974	America	Multicenter	1946–1968	TA, unclassified	50 (0.43)	NR	NR	7
Kunjumohamed et al,^Citation28 2015	Oman	Single center	2007–2013	TA, TMG	23 (32.39)	17–76	59 (83.1)	7
Linos et al,^Citation29 1997	Greece	Single center	1982–1991	TNG, TN	27 (6.75)	39	338 (84.5)	5
Mittenforf and McHenry,^Citation30 2001	America	Single center	1990–1998	Thyroiditis, TMG	6 (11.11)	42	44 (80)	7
Ocak et al,^Citation31 2014	Turkey	NR	2005–2010	TMG, UTG	13 (7.34)	45.9	134 (75.7)	5
Pradeep et al,^Citation32 2007	India	Single center	1990–2005	TMG	19 (5.85)	39.86	249 (76.7)	7
Ruggieri et al,^Citation33 1999	Italy	Single center	1994–1999	TMG, autonomous nodule	6 (7.32)	52	60 (73)	7
Terzioglu et al,^Citation34 1993	Italy	Single center	1986–1991	TNG, TA	8 (5.80)	43.1	NR	5
Wahl et al,^Citation35 1982	Germany	Multicenter	1962–1979	TMG, UTG	18 (2.56)	NR	NR	7
Zanella et al,^Citation36 2001	Italy	Single center	NR (20 years)	TMG, TA	12 (6.06)	53.5	148 (73.2)	8
Quérat et al,^Citation37 2015	France	Single center	2004–2012	TMG, amiodarone	25 (12.50)	55.7	33 (80.5)	7

Abbreviations: ITC, incidental thyroid carcinoma; NOS, Newcastle–Ottawa scale; TA, toxic adenoma; TMG, toxic multinodular goiter; TNG, toxic nodular goiter; TN, toxic nodule; UTG, toxic uninodular goiter; NR, not reported.

Figure 1 Flow diagram of study selection.

Figure 2 Forest plot for the overall estimate of the prevalence of thyroid cancer.

Abbreviations: ES, effect size; CI, confidence interval.

Figure 3 Forest plot for the pooled OR in surgery-treated hyperthyroid patients with and without GD.

Abbreviations: GD, Graves’ disease; OR, odds ratio; CI, confidence interval; M–H, Mantel–Haenszel.

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