Prognostic factors for postoperative survival among patients with rhabdomyosarcoma of the limbs

Figures & data

Table 1 Clinical characteristics of 385 patients with RMS of the limbs after surgery identified in the SEER database from 1983 to 2013

Category	Value
Age at diagnosis (years)
<20	164 (42.6%)
20–40	52 (13.5%)
>40	169 (43.9%)
Gender
Female	161 (41.8%)
Male	224 (58.2%)
Decade of diagnosis
<2000s	99 (25.7%)
≥2000sa	286 (74.3%)
Location
Upper	135 (35.1%)
Lower	250 (64.9%)
Tumor stage
Localized	194 (50.4%)
Regional	125 (32.5%)
Distant	66 (17.1%)
Tumor size
<5 cm	103 (26.8%)
5–10 cm	186 (48.3%)
>10 cm	96 (24.9%)
Radiation treatment
Yes	240 (62.3%)
No	145 (37.7%)
Dead
Yes	196 (50.9%)
No	189 (49.1%)
5-year OS rate	51.5%
5-year CSS rate	56.7%
10-year OS rate	42.2%
10-year CSS rate	50.7%

Note:

a 2000–2013 year.

Abbreviations: SEER, Surveillance, Epidemiology, and End Results; OS, overall survival; CSS, cancer-specific survival, RMS, Rhabdomyosarcoma.

Table 2 Univariate analysis of variables in patients with RMS of the limbs after surgery using the Kaplan–Meier method

Category	OS (log-rank P-value)	CSS (log-rank P-value)
Age at diagnosis (years)	<0.001	<0.001
>40 vs <20	<0.001	<0.001
>40 vs 20–40	0.173	0.662
20–40 vs <20	0.002	0.003
Gender	0.431	0.151
Decade of diagnosis	0.675	0.191
Location	0.008	0.072
Tumor stage	<0.001	<0.001
Distant vs localized	<0.001	<0.001
Distant vs regional	<0.001	<0.001
Regional vs localized	0.292	0.205
Tumor size	<0.001	<0.001
>10 cm vs 5–10 cm	<0.001	<0.001
>10 cm vs <5 cm	<0.001	<0.001
5–10 cm vs <5 cm	0.081	0.032
Radiation treatment	<0.001	0.006

Note: Statistically significant values (P<0.05) are indicated in bold.

Abbreviations: OS, overall survival; CSS, cancer-specific survival; RMS, Rhabdomyosarcoma.

Figure 1 Kaplan–Meier method estimated OS in patients with RMS of the limbs after surgery, stratified by (A) age at diagnosis (years), (B) tumor stage, (C) tumor size (cm), and (D) radiation treatment.

Abbreviations: OS, overall survival; RMS, rhabdomyosarcoma.

Figure 2 Kaplan–Meier method estimated CSS in patients with RMS of the limbs after surgery, stratified by (A) age at diagnosis (years), (B) tumor stage, (C) tumor size (cm), and (D) radiation treatment.

Abbreviations: CSS, cancer-specific survival; RMS, rhabdomyosarcoma.

Table 3 Multivariate analysis for OS and CSS for patients with RMS of the limbs after surgery

Variable	OS		CSS
	HR (95% CI)	P-value	HR (95% CI)	P-value
Age (years)		<0.001		<0.001
<20	1		1
20–40	2.206 (1.379–3.530)	0.001	2.213 (1.334–3.670)	0.002
>40	3.313 (2.333–4.704)	<0.001	2.805 (1.865–4.217)	<0.001
Location		0.327		–
Upper	1		–
Lower	1.172 (0.853–1.609)	0.327	–	–
Tumor stage		<0.001		<0.001
Localized	1	0.170	1
Regional	1.280 (0.899–1.820)		1.384 (0.909–2.108)	0.129
Distant	5.043 (3.389–7.504)	<0.001	5.357 (3.391–8.463)	<0.001
Tumor size		0.003		0.006
<5 cm	1		1
5–10 cm	1.165 (0.797–1.703	0.431	1.332 (0.834–2.128)	0.230
>10 cm	1.945 (1.263–2.996)	0.003	2.204 (1.310–3.706)	0.003
Radiation treatment		<0.001		0.011
Yes	1		1
No	1.703 (1.279–2.267)	<0.001	1.559 (1.108–2.193)	0.011

Note: Statistically significant values (P<0.05) are indicated in bold.

Abbreviations: OS, overall survival; CSS, cancer-specific survival; HR, hazard ratio; RMS, rhabdomyosarcoma.

Table S1 Subtypes of 385 patients with RMS of the limbs after surgery identified in the SEER database from 1983 to 2013

Subtype of RMS	Value
RMS, NOS	57 (14.8%)
Pleomorphic type	117 (30.4%)
Mixed type	3 (0.8%)
Embryonal type	47 (12.2%)
Spindle cell type	18 (4.7%)
Alveolar type	143 (37.1%)

Abbreviations: SEER, Surveillance, Epidemiology, and End Results; RMS, rhabdomyosarcoma; NOS, not otherwise specified.