Figures & data
Figure 1 ERRα, a hot topic.
Notes: PubMed, total number of times reported in the literature. GO, number of biological processes participating in the Gene Ontology database. miRNA, number of documented miRNAs. Disease, number of diseases associated with the published literature. Pathway, signals participating in Kyoto Encyclopedia of Genes and Genomes (KEGG) database. Gray spot (median), position at the level of the number of pathways in which genes participate in the signal. Green spot, the relative position of the number of ERRα participants at the signal pathway level.
Abbreviation: ERRα, estrogen-related receptor α.
Figure 2 Genes related to ERRα obtained from STRING database analysis.
Notes: Each node represents different proteins: among them, <img> is the target protein of ERRα. Edges: <img>, from the curated database; <img>, experimentally determined; the remaining colors are all predicted interactions.
Abbreviation: ERRα, estrogen-related receptor α.
Figure 3 The potential mechanism of ERRα in energy metabolism: the PGC-1α/ERRα axis, as the key point of energy metabolism in cancer cells, is involved in mediating the metabolism of lipids, glycolysis, and glutamine through transcription factors that affect the bioenergetics of cancer cells, and then changes the behavior of invasion, metastasis and drug resistance of cancer cells.
Abbreviations: ERRα, estrogen-related receptor α; PPAR γ, peroxisome-proliferator activated receptor γ; FASN, fatty acid synthase; TCA, tricarboxylic acid cycle; ROS, reactive oxygen species.
