Stereotactic Radiotherapy for Parasagittal and Parafalcine Meningiomas: Patient Selection and Special Considerations

Figures & data

Table 1 Patient and Treatment Characteristics of the Analyzed Studies

Authors, Year (Ref)	N of pts	WHO Grade	Previous Surgery, N	Number of Fractions	Prescription or Marginal Dose, Gy	Median Tumor Diameter or Volume	Median Fup After RS, Months	LC, Type	Rate (PR+SD), %	Toxicity, Type	Toxicity Rate, %	Toxicity, Type	Toxicity Rate, %
Sheehan JP, 2015(16)	212	I, II, III	59.9%	1	14	8.4 mL	19.6	Volume	GI 81.9 GII 60.7 GIII 33.3	Edema	5.2	RT-induced Cyst	7.1
Hasegawa T, 2011 (19)	108	I	59%	1	16	24.7 mm	72	± 2 mm in any direction	85	Edema, motor weakness, seizures, headache
Ding D, 2013 (8)	65	I	80%	1	14	3 cc	48.6	NR	72.3	Edema	40.4	Seizures Encephalomalacia	14.3 7.7
Patil CG, 2008 (20)	31	I, II, III	NR	1-5	18.48-18	6.7 cc	20.9	NR	NR	Edema	29	-	-
Kondziolka, 1998 (21)	185	NN	62%	1	15	10 cc	NR	NR	85	Symptomatic Edema	9.7	Actuarial 3- and 5-year symptomatic edema	16

Abbreviations: pts, patients; N, number; Fup, follow-up; RS, radiosurgery; LC, local control; NR, not reported.

Table 2 Radiation-Induced Edema Characteristics of the Analyzed Studies

Authors, Year (Ref)	Edema pre-RT, %	Number of Fractions	Dose, Gy	Regression Edema, %	Worsened Edema, %	Post-RT Edema, %	Time of Onset, Months	Factors Edema-Related	Use of Steroids, %	Other Treatments, %
Sheehan JP, 2015(16)	45.3	1	14	26.4	5.2	5.2	(6–24)	- Tumor volume > 10cc, - Venous sinus compression/invasion -Parasagittal - High max dose - High marginal dose	15.1	Bevacizumab, 2.4
Hasegawa T, 2011 (19)	3.7	1	16	NR	NR	NR	NR	- Fewer prior treatments - Low margin dose
Ding D, 2013 (8)	NR	1	14	NR	NR	40.4	NR	NR	8.1	NR
Patil CG, 2008 (20)	0	1-5	18.48-18	NR	NR	29	7	Midline parasinus location	73	NR
Kondziolka D, 1998 (21)	NR	1	15	NR	NR	9.7	1-23	Pre-RT neurological deficit No previous resection	NR	NR

Abbreviations: RT, radiotherapy; NR, not reported.