High-grade endometrial stromal sarcoma: a retrospective study of factors influencing prognosis

Figures & data

Table 1 Clinical characteristics of patients

Variable	No. of patients (%)
Age at diagnosis, median (range)	48.5 years (16–73 years)
Menopause	21 (52.5)
Parity (≥1)	31 (82.5)
Unknown	2 (5)
History of uterine leiomyomaa	27 (67.5)
Initial symptoms
Postmenopausal bleeding	14 (35)
Menorrhagia/irregular bleeding	12 (30)
Abdominal discomfort	12 (30)
Paruria	7 (17.5)
Tumor grew like a polyp	8 (20)
Tumor size, median (range)a	7.9 cm (2–19 cm)
<5 cm	6 (15)
≥5 cm	30 (75)
Unknown	4 (10)
Serum CA125 level (U/mL), median (range)a
Maximum value	34.05 (3.2–679.6)
Minimum value	9.12 (2.9–22.8)
Mean value	17.93 (3.08–290.3)
Curettage/biopsy	26 (65)
Positive	22 (84.6)
Ovarian conservation	6 (15)
Depth of invasion (≥1/2)	26 (65)
Lymphadenectomya	15 (37.5)
Positive	3 (20)
Peritoneal lavage cytology	12 (30)
Positive	0 (0)
Lymphovascular space invasiona	18 (45)
Uterine fibroidsa	13 (32.5)
Endometriosisa	11 (27.5)
Omentectomya	16 (40)
Positive	4 (25)
FIGO stage (2009)a
I	17 (42.5)
II	8 (20)
III	9 (22.5)
IV	6 (15)
Chemotherapya	33 (82.5)
Radiotherapya	13 (32.5)
Hormone therapya	5 (12.5)

Note:

a The factors that we used to evaluate the prognosis of patients with HG-ESS.

Abbreviations: FIGO, Federation of Gynecology and Obstetrics; HG-ESS, high-grade endometrial stromal sarcoma.

Table 2 Treatment of patients

Treatment	No. of patients (%)
	Early stage (stage I) N=17	Late stage (stage II–IV) N=23
Surgery	3 (17.7)	4 (17.4)
Surgery + chemotherapy	6 (35.3)	9 (39.1)
Surgery + chemotherapy + radiation	4 (23.5)	9 (39.1)
Surgery + chemotherapy + hormonotherapy	4 (23.5)	1 (4.4)

Figure 1 Progress-free survival of patients with or without endometriosis.

Abbreviation: PFS, progress-free survival.

Figure 2 OS of patients: (A) stage, (B) menopause, (C) history of uterine leiomyoma, and (D) endometriosis.

Abbreviation: OS, overall survival.

Figure 3 Comparative analysis of PFS in early-stage patients according to the treatment methods.

Abbreviation: PFS, progress-free survival.