The role of long non-coding RNA GAS5 in cancers

Figures & data

Figure 1 The biological processes regulated by LncRNA GAS5.

Figure 2 The function of LncRNA GAS5 in various cancers.

Table 1 Related miRNAs in various cancers and lower expression of lncGAS5 is associated with clinical features

Cancer type	Related miRNA	Clinicopathological features
Colorectal cancer	miR-103, miR-221	Larger tumor size, low histological grade, advanced TNM stage, poor
		Prognosis, lymph node metastasis, local recurrence rate, distant metastasis rate
Cervical cancer	miR-196a, miR-205	Advanced FIGO stage and metastatic parameter, poorer overall survival
Gastric cancer	miR-222, miR-23a	Larger tumor size, advanced pathologic stage, poorer DFS, poorer OS
Pancreatic cancer	miR-181c-5p	Chemotherapeutic drug resistance, promote tumorigenesis and metastasis
Hepatocellular carcinoma	miR-21	Poor prognosis, differentiation, portal vein
Prostate cancer	miR-103	Poor outcome
Breast cancer	miR-21	Trastuzumab resistance
NSCLC	miR-23a, miR-135b	Advanced TNM stages and larger tumor size, poor tumor differentiation
Glioma cancer	miR-196a-5p, miR-222	-
Osteosarcoma	miR-203a	-
Melanoma	miR-137	-
Bladder cancer	-	Higher pathological grades, poor disease free survival,
		Enhance the chemotherapy resistance to doxorubicin
Thyroid cancer	-	Advanced TNM stages, lymph node metastasis, poor DFS, poor OS
Head and neck cancer	-	Higher complete response rate

Abbreviations: NSCLC, non-small cell lung cancer; DFS, disease free survival; OS, overal survival.