Function of microRNA-145 and mechanisms underlying its role in malignant tumor diagnosis and treatment

Figures & data

Table 1 MiR-145 target molecules and consequences of their targeting in common tumors

Tumor type	Target molecule	Effect	Reference
Thyroid cancer	PI3K/AKT	Differentiation, proliferation, invasion, metastasis	^Citation44
Non-small-cell lung cancer	AEG-1/MTDH	Invasion, metastasis	^Citation89
	PI3K/AKT, RAS/ERK	Differentiation, proliferation, invasion, metastasis	^Citation27
	Oncolytic HSV-1	Sensitivity	^Citation64
	c-Myc	Proliferation	^Citation80
Lung adenocarcinoma	OCT4	Proliferation, endothelial-mesenchymal transition	^Citation90
	FR, NUDT1	Differentiation, proliferation, invasion, metastasis	^Citation26
	N-cadherin	Invasion, metastasis	^Citation34
Liver cancer	ADAM17	Proliferation	^Citation91
	IRS1	Proliferation	^Citation83
Pancreatic cancer	MUC13/HER2	Proliferation, invasion	^Citation66
	MUC13, ERBB2	Proliferation, invasion, sensitivity	^Citation65
	p70S6K1	Sensitivity	^Citation14
	SET, RPA1, MCM2, ABCC1, SPTBN1, SPTLC1	Proliferation	^Citation62
Colorectal cancer	PPAR-γ/SOX9	Differentiation	^Citation23
	mTOR/p70S6K1	Proliferation, angiogenesis	^Citation29
	DFF45	Proliferation	^Citation82
	FLI1	Invasion, metastasis	^Citation88
	YES, STAT1	Proliferation	^Citation21
Gastric cancer	IRS-1/β-actin	Proliferation	^Citation92
Gut tumors	ERK5/c-Myc, p68/p72/β-catenin	Proliferation	^Citation28
Bladder cancer	IGF-IR/PAK1 SENP1	Proliferation, invasion Proliferation, invasion, metastasis	^Citation93,Citation94 ^Citation30
	FSCN1	Proliferation	^Citation76
Renal cell carcinoma	MMP-11	Proliferation, invasion	^Citation49
	HIF2α/VEGF/MMP9/CCND1	Invasion, metastasis	^Citation59
	ADAM17, c-Myc	Proliferation, sensitivity	^Citation77,Citation78
Prostate cancer	TNFSF-10	Proliferation	^Citation29
	PCGEM1	Proliferation, invasion, metastasis, sensitivity	^Citation58
	FSCN1	Proliferation, invasion, metastasis	^Citation8
Urothelial cancer	Caspase	Proliferation	^Citation79
Breast cancer	MUC1	Invasion, metastasis	^Citation81
	JAM-A, fascin	Metastasis	^Citation33
	RTKN	Proliferation	^Citation81
	ER-alpha	Proliferation	^Citation63
Ovarian cancer	MTDH	Proliferation	^Citation95
	Cdk6, Sp1, ABCB1, RB1	Sensitivity	^Citation66
Osteosarcoma	ROCK1	Proliferation, invasion	^Citation87
Chondrosarcoma	SOX9, ETV-5, MMP-2	Metastasis	^Citation57
Pleural mesothelioma	OCT4/ZEB1	Proliferation, invasion, sensitivity	^Citation20
Glioma	RhoA/ROCK1	Invasion	^Citation84
Invasive glioblastoma	srGAP1	Invasion	^Citation86

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