Preoperative neutrophil–lymphocyte and platelet–lymphocyte ratios as independent predictors of T stages in hilar cholangiocarcinoma

Figures & data

Table 1 Patient characteristics and pathological findings in patients with different T stages (≧T2b or ＜T2b)

Characteristic	T stage≧T2b (n=29)	T stage＜T2b (n=72)	P
Age, mean±SD	58.24±9.98	60.93±9.85	0.219
Grade			0.68
High	10 (34.5%)	28 (38.9%)
Moderate	17 (58.6%)	36 (50%)
Low	2 (6.9%)	8 (11.1%)
Lymph node			0.001
Positive	16 (55.2%)	15 (20.8%)
Negative	13 (44.8%)	57 (79.2%)
Tumor location			＜0.001
Above junction	26 (89.7%)	32 (44.4%)
Below junction	3 (10.3%)	40 (55.6%)

Table 2 Effect of univariate and multivariate variables on the T stage (≧T2b or ＜T2b)

Variable		Univariate			Multivariate
	OR	95% CI	P	OR	95% CI	P
≧CO versus＜CO
NLR	5.91	2.22–15.73	＜0.001	3.74	1.09–12.83	0.036
PLR	8.62	3.26–22.82	＜0.001	7.86	2.25–27.43	0.001
Lymph node	4.68	1.85–11.82	0.001	4.97	1.42–17.43	0.012
Grade
High	Reference
Moderate	2.23	0.23–21.37	0.49
Low	2.63	0.29–23.64	0.39
Tumor location	10.8	3.01–39.05	＜0.001	14.46	2.94–71.14	0.001

Note: The CO for NLR is 2.75; the CO for PLR is 172.25.

Abbreviations: CO, cutoff value; NLR, neutrophil–lymphocyte ratio; PLR, platelet–lymphocyte ratio.

Table 3 Mean white blood cell subtype counts, neutrophil–lymphocyte ratio, and platelet–lymphocyte ratio in study subjects

Characteristic	T stage≧T2b	T stage＜T2b	P
WBC	7.15±2.66	6.41±1.87	0.114
Neutrophils	6.18±2.59	4.02±1.51	＜0.001
Lymphocytes	1.76±0.55	1.72±0.64	0.794
Platelets	303.95±130.33	222.07±72.69	0.003
NLR	3.61±1.32	2.66±1.41	0.002
PLR	181.56±44.98	141.32±43.79	＜0.001

Note: Values are expressed as the mean±SD.

Abbreviations: NLR, neutrophil–lymphocyte ratio; PLR, platelet–lymphocyte ratio; WBC, white blood count.

Figure 1 Receiver-operating curve for the relationship between the NLR and PLR and the T stage (≧T2b or ＜T2b).

Notes: Areas under the curve for the NLR and PLR are 0.758 (95% CI 0.619–0.825, P=0.001) and 0.722 (95% CI 0.654–0.862, P＜0.001), respectively.

Abbreviations: NLR, neutrophil–lymphocyte ratio; PLR, platelet–lymphocyte ratio; ROC, receiver-operating characteristic.