Oncologic outcome of parotid mucoepidermoid carcinoma in pediatric patients

Figures & data

Table 1 Detailed information of pediatric patients with IPN metastasis

Case	Age (years)	Sex	Disease stage	Tumor grade	NLR	PI	LVI	Margin	Treatment	Outcome
1	9	M	IV	High	3.0	Yes	Yes	Positive	S+R+C	Died
2	17	F	III	Low	6.0	No	No	Negative	S	Alive
3	17	F	III	Low	1.4	Yes	No	Negative	S+R	Alive
4	16	M	I	Medium	2.2	No	No	Negative	S	Alive
5	15	F	II	Medium	2.6	No	Yes	Negative	S	Alive
6	16	M	IV	Medium	4.4	No	No	Negative	S	Died
7	14	F	III	High	1.6	Yes	Yes	Positive	S+R+C	Died
8	15	F	III	Low	3.9	No	No	Negative	S+R	Alive
9	14	M	IV	High	2.0	No	Yes	Positive	S+R	Died
10	16	F	II	Low	1.9	No	No	Negative	S	Alive
11	11	M	I	Low	2.3	No	No	Negative	S	Alive
12	15	F	II	Medium	1.8	Yes	No	Negative	S+R	Alive
13	10	M	III	Medium	3.0	No	No	Negative	S	Died

Abbreviations: C, chemotherapy; F, female; IPN, intraparotid node; LVI, lymphovascular invasion; M, male; NLR, neutrophil-to-lymphocyte ratio; PI, perineural invasion; R, radiotherapy; S, surgery.

Table 2 Risk factors for loco-regional recurrence in pediatric patients with parotid cancer

	Univariate	Multivariate (OR [95% CI])
Age (<14 vs ≥14)	0.223
Sex (male vs female)	0.156
Tumor stage (T1 + T2 vs T3 + T4)	<0.001	0.568 (3.146 [0.079–12.223])
Node stage (N0 vs N+)	0.091
IPN metastasis	<0.001	0.03 (2.223 [1.658–5.897])
Tumor grade (low+ moderate vs high)	0.003	0.019 (1.985 [1.396–4.033])
Nerve infiltration	0.238
LVI	<0.001	0.020 (2.004 (1.567–4.229))
Margin status	0.119
Radiotherapy	0.592
Lymphocyte-to-monocyte ratio	0.030	0.153 (3.018 [0.485–10.228])

Abbreviations: IPN, intraparotid node; LVI, lymphovascular invasion.

Table 3 Risk factors for disease-related death in pediatric patients with parotid cancer

	Univariate	Multivariate (OR [95% CI])
Age (<14 vs ≥14)	0.468
Sex (male vs female)	0.332
Tumor stage (T1 + T2 vs T3 + T4)	0.013	0.016 (2.167 [1.288–5.412])
Node stage (N0 vs N+)	0.089
IPN metastasis	<0.001	0.013 (1.897 [1.142–4.656])
Tumor grade (low + moderate vs high)	0.198
Nerve infiltration	0.003	0.326 (3.556 [0.298–12.331])
LVI	<0.001	0.102 (3.231 [0.696–10.141])
Margin status	0.387
Radiotherapy	0.144
Lymphocyte-to-monocyte ratio	0.263

Abbreviations: IPN, intraparotid node; LVI, lymphovascular invasion.