Cervical cancer in women aged 25 years or younger: a retrospective study

Figures & data

Table 1 Demographic and clinical characteristics of cervical cancer patients aged ≤25 years

Clinical characteristics	Cervical carcinoma		Cervical sarcoma		Total cohort
	(N=44)		(N=16)		(N=60)
	n	%	n	%	n	%
Median age (years)	24		16		23
History of sexual behavior
Yes	34	77.3	3	18.8	37	61.7
No	10	22.7	13	81.2	23	38.3
Symptoms
Post-coital bleeding	21	47.7	0	0.0	21	35.0
Abnormal vaginal bleeding	16	36.4	8	50.0	24	40.0
Cervical polypoid mass	1	2.3	7	43.8	8	13.3
Cervical cancer screening	3	6.8	0	0.0	3	5.0
Others	3	6.8	1	6.2	4	6.7
Histology
Type of carcinoma
Squamous cell carcinoma	22	50.0			22	36.6
Adenocarcinoma	18	40.9			18	30.0
Others	4	9.1			4	6.7
Type of sarcoma
Embryonal rhabdomyosarcoma			8	50.0	8	13.3
Endometrial stromal sarcoma			4	25.0	4	6.7
Others			4	25.0	4	6.7
Stage
I	26	59.1	14	87.5	40	66.7
II	13	29.5	0	0.0	13	21.7
III	2	4.5	0	0.0	2	3.3
IV	3	6.8	2	12.5	5	8.3
Surgery
Conization	3	6.8	0	0.0	3	5.0
Radical trachelectomy	8	18.2	0	0.0	8	13.3
Radical hysterectomy	20	45.5	1	6.3	21	35.0
Polypectomy	0	0.0	15	93.8	15	25.0

Table 2 Fertility results and pregnancy outcomes of eleven cervical carcinoma patients with fertility-sparing surgeries

Pregnancy outcomes	Number	Percent (%)
Attempted to conceive	7	7/11(63.6)
Achieved pregnancy	4	4/7(57.1)
Total pregnancies	6
Live births	4	4/6(66.7)
Miscarriages	2	2/6(33.3)
Recurrence	1	1/11(9.1)

Figure 1 Kaplan–Meier curve showing overall survival in 60 cervical cancer patients aged ≤25 years.

Figure 2 Kaplan-Meier curve showing overall survival among women ≤25 years with cervical carcinoma and cervical sarcoma.

Table 3 Univariate analysis of prognostic risk factors in 44 young cervical carcinoma patients

Prognostic factors	5-Year survival rate	P-value
Histologic subtype
Squamous carcinoma	94.4	0.003a
Non-squamous carcinoma	53.0
Stage
IA1–IIA2	86.0	0.001a
IIB–IV	36.4
Pelvic LN metastasis
Yes	37.3	0.001a
No	94.7
Differentiation
G1	74.9	0.909
G2/G3	74.6

Note:

a P<0.05 indicated statistically significant differences.

Abbreviation: LN, lymph node.

Table 4 Multivariate analysis of prognostic risk factors in 44 young cervical carcinoma patients

Prognostic factors	RR	95% CI	P-value
Stage	6.71	(1.366, 32.970)	0.019a
Pelvic LN metastasis	9.09	(1.050, 78.732)	0.045a
Non-squamous	3.07	(0.314, 29.978)	0.335
carcinoma

Note:

a P<0.05 indicated statistically significant differences.

Abbreviation: LN, lymph node.