Radiotherapy for patients with completely resected pathologic IIIA(N2) non–small-cell lung cancer: a retrospective analysis

Figures & data

Table 1 Baseline characteristics of the 115 patients

Clinical feature	Total (%)	PORT(%)	Non-PORT(%)
All patients	115(100)	46(100)	69(100)
Gender
Male	80(69)	34(74)	46(67)
Female	35(31)	12(26)	23(33)
Age (years)
<60	63(55)	31(67)	32(46)
≥60	52(45)	15(33)	37(54)
ECOG scores
0	61(53)	30(65)	31(45)
1	47(41)	14(30)	33(48)
2	7(6)	2(5)	5(7)
Smoking status
Never-smoker	54(47)	23(50)	21(30)
Previous or current smoker	61(53)	23(50)	39(70)
Histological subtype
Adenocarcinoma	75(65)	31(67)	44(64)
Squamous carcinoma	34(30)	12(26)	22(32)
Others	6(5)	3(7)	3(4)
EGFR mutations
Mutant	36(31)	15(33)	21(30)
Wild type	79(69)	31(67)	48(70)
Pathological stage
PT1N2	37(32)	12(26)	25(36)
PT2N2	66(57)	30(65)	33(48)
PT3N2	12(11)	4(9)	8(11)
Type of surgery
Lobectomy	91(79)	40(87)	51(74)
Sleeve lobectomy	13(11)	6(13)	7(15)
Pneumonectomy	11(10)	0(0)	11(16)
Cycles of POCT
<4	41(36)	18(39)	23(33)
≥4	74(64)	38(61)	46(67)
Number of total involved nodes
<2	43	13	30
≥2	72	33	39

Table 2 Univariate analysis of PFS and OS according to baseline characteristics

Variables	PFS			OS
HR	95%CI	P-value	HR	95%CI	P-value
Gender	0.954	0.608–1.496	0.838	1.045	0.670–1.632	0.845
Male
Female
Age(years)	1.572	1.040–2.374	0.032	2.066	1.367–3.122	0.001
<60
≥60
Smoking status	0.840	0.545–1.247	0.036	0.705	0.463–1.074	0.011
Never-smoker
Previous or current smoker
Histological subtype	1.244	0.784–1.974	0.696	1.076	0.690–1.677	0.560
Non-squamous
Squamous
EGFR mutations	0.829	0.528–1.300	0.004	0.669	0.417–1.073	0.025
Mutant
Wild type
Pathological stage	0.941	0.623–1.441	0.790	0.872	0.66–1.54	0.512
PT1N2
PT2N2
PT3N2
Type of surgery	1.566	1.066–2.299	0.022	1.215	0.806–1.831	0.231
Lobectomy
Pneumonectomy
Cycles of POCT	0.598	0.432–0.827	0.002	0.669	0.475–0.942	0.021
<4
≥4
Number of total involved nodes	0.873	0.613–1.244	0.004	0.712	0.505–1.003	0.049
<2
≥2
Planned radiotherapy	2.306	1.459–3.645	<0.001	2.814	1.759–4.503	<0.001
Yes
No

Table 3 Multivariate analyses of PFS and OS according to baseline characteristics

Variables	PFS			OS
HR	95%CI	P-value	HR	95%CI	P-value
Age(years)	0.944	0.602–1.482	0.803	0.850	0.544–1.331	0.478
<60
≥60
Smoking status	0.901	0.187–4.348	0.897	0.811	0.160–4.124	0.801
Never-smoker
Previous or current smoker
EGFR mutations	0.810	0.499–1.314	0.393	0.704	0.430–1.154	0.164
Mutant
Wild type
Type of surgery	1.511	0.982–2.145	0.074	1.332	0.759–1.784	0.053
Lobectomy
Pneumonectomy
Cycles of POCT	1.555	0.863–2.802	0.042	1.432	0.808–2.537	0.002
<4
≥4
Number of total involved nodes	1.113	0.236–4.243	0.002	1.089	0.222–4.343	0.017
<2
≥2
Planned radiotherapy	2.242	1.405–3.578	0.001	2.676	1.654–4.327	<0.001
Yes
No

Figure 1 Kaplan-Meier progression-free survival curve.

Figure 2 Kaplan-Meier overall survival curve.