Transcriptional Characterization Of The Tumor Immune Microenvironment And Its Prognostic Value For Locally Advanced Lung Adenocarcinoma In A Chinese Population

Figures & data

Table 1 Baseline Characteristics Of Patients With Advanced Lung Adenocarcinoma From Xiangya Hospital

Characteristic	Favorable Prognosis (n=12)	Poor Prognosis (n=12)	P value
Age (years)
≥60	4	8	>0.05
<60	8	4
Sex
Male	8	8	>0.05
Female	4	4
T Stage
T1	6	6	>0.05
T2	4	4
T3	2	2
N Stage
N1	3	1	>0.05
N2	9	11
Differentiation
High	3	4	>0.05
Medium	7	2
Low	2	6

Figure 1 (A) Volcano plot of the expression of immune-related genes in patients with favorable rather than poor prognoses. (B) Heatmap of DEGs in patients with favorable and poor prognoses. (C) Boxplots of DEGs in patients with favorable and poor prognoses (center line: median, box: second and third quartiles, bars: 95% CI, points: outliers).

Figure 2 Heat map of GSVA enrichment scores of immune-related pathways in patients with favorable and poor prognoses.

Table 2 Univariate And Multivariate Cox Hazard Analysis Of The Association Of Different Tumor Immunological Infiltrates With PFS (Xiangya Hospital Data, N = 24)

Cell Type	Univariate Cox Hazard Analysis			Multivariate Cox Hazard Analysis
HR	95% CI	P	aHR	95% CI	P
T cells	1	0.68–1.48	0.996	NA	NA	NA
CD8 T cells	0.78	0.48–1.25	0.298	NA	NA	NA
Cytotoxic lymphocytes	1.12	0.72–1.76	0.612	NA	NA	NA
NK cells	1.51	0.96–2.39	0.076	NA	NA	NA
B lineage	1	0.63–1.6	0.992	NA	NA	NA
Monocytic lineage	1.01	0.67–1.51	0.98	NA	NA	NA
Neutrophils	1.72	1.12–2.65	0.014	1.67	1.09–2.55	0.019
Endothelial cells	0.91	0.61–1.38	0.668	NA	NA	NA

Abbreviations: HR, hazard ratio; CI95, 95% confidence interval; NA, non-available.

Figure 3 Kaplan-Meier survival analyses of the relationships of different immunological infiltrates with DFS, in which the median value of each MCP-counter score of immune infiltrates was used as the cutoff (Xiangya Hospital LUAD data, n = 24).

Figure 4 Forest plot showing multivariate Cox regression analysis of the effect of different tumor immunological infiltrates on DFS (TCGA LUAD data, n = 85). *P<0.05; **P<0.01.

Figure 5 Forest plot showing multivariate Cox regression analysis of the effect of different tumor immunological infiltrates on OS (TCGA LUAD data, n = 85). *P<0.05; **P<0.01; ***P<0.001.