Prognostic Value Of The Preoperative Neutrophil To Lymphocyte Ratio In Patients With Sinonasal Squamous Cell Carcinoma

Figures & data

Table 1 Patient Characteristics

Varibles	No./Mean ± SD
Age (years)	61.33 ± 13.31
Gender
Male	123
Female	24
Smoking status
Never smoked	21
Smoked in past	126
BMI (kg/m^2)	24.13 ± 3.31
Tumor size
<2.5cm	89
≥2.5cm	58
Histological type
Low	31
Medium	84
High	32
Pathological T stage
T1	21
T2	61
T3	33
T4	32
Pathological N stage
Negative (NX, N0)	51
Positive (N1, N2, N3)	96
Surgery
Endoscopic resection	44
Endoscopic resection + Lateral rhinotomy	103
Laboratory
Albumin, g/l	42.32 ± 5.43
Hemoglobin, g/dl	127.45 ± 20.56
White blood cell count, 10^9/L	7.11 ± 2.98
Neutrophil count, 10^9/L	4.88 ± 2.91
Platelet count, 10^9/L	229.91 ± 74.25
NLR	4.19 ± 1.33

Abbreviations: BMI, Body Mass Index; NLR, neutrophil to lymphocyte ratio.

Figure 1 OS (A), DSS (B) and DFS (C) curves of patients with high NLR versus those with low NLR.

Table 2 Univariate And Multivariate Cox Hazards Analysis For OS In Patients With SSCC

Varibles	Univariate Analysis		Multivariate Analysis
HR (95% CI)	p-value	HR(95% CI)	p-value
Age (years)		0.347
>58	1
≤58	0.339(0.132–1.627)
Gender		0.535
Male	1
Female	1.369(0.594–1.724)
Smoking status		0.021		0.698
Never smoked	1		1
Smoked in past	1.209(1.013–1.875)		0.935(0.285–1.941)
BMI(kg/m^2)		0.011		0.588
≤22.45	1		1
>22.45	1.209(1.011–2.033)		0.881(0.215–1.228)
Tumor size		0.665
≤2.5cm	1
>2.5cm	1.559(0.433–3.381)
Histological type		0.002		0.351
High	1		1
Medium, low	1.756(1.553–2.663)		1.031(0.484–2.015)
Pathological T stage		<0.001		<0.001
T1, T2	1		1
T3, T4	1.669(1.353–3.664)		1.719(1.277–3.642)
Pathological N stage		<0.001		<0.001
Negative(NX, N0)	1
Positive(N1, N2, N3)	1.214(1.052–2.617)		1.344(1.015–2.776)
Surgery		0.547
Nasal endoscopy	1
Nasal endoscopy + Lateral rhinotomy	1.570(0.255–4.114)
Albumin(>38.3/≤38.3, g/l)	1.187(0.746–1.665)	0.441
Hemoglobin(>128/≤128), g/dl)	0.414(0.139–1.439)	0.571
WBC count, (>8.34/≤8.34, 10^9/L)	1.145(0.343–1.549)	0.648
Neutrophil count, (>5.44/≤5.44, 10^9/L)	1.975(0.644–2.988)	0.773
Platelet count, (>198/≤198, 10^9/L)	1.804(0.773–2.191)	0.761
NLR		<0.001		0.002
High (≤4.25)	1		1
Low(>4.25)	1.888(1.336–3.342)		1.579(1.217–3.092)

Abbreviations: BMI, Body Mass Index; NLR, neutrophil to lymphocyte ratio.

Table 3 Univariate And Multivariate Cox Hazards Analysis For DFS In Patients With SSCC

Varibles	Univariate Analysis		Multivariate Analysis
HR (95% CI)	p-value	HR (95% CI)	p-value
Age (years)		0.322
>58	1
≤58	0.357(0.119–1.510)
Gender		0.472
Male	1
Female	1.447(0.699–1.919)
Smoking status		0.033		0.783
Never smoked	1		1
Smoked in past	1.312(1.055–1.967)		0.881(0.253–1.749)
BMI(kg/m^2)		0.025		0.672
≤22.45	1		1
>22.45	1.371(1.075–1.939)		0.654(0.197–1.134)
Tumor size		0.588
≤2.5cm	1
>2.5cm	1.479(0.513–3.099)
Histological type		0.014		0.516
High	1		1
Medium, low	1.667(1.379–2.501)		1.266(0.571–2.233)
Pathological T stage		<0.001		<0.001
T1, T2	1		1
T3, T4	1.578(1.362–3.546)		1.835(1.141–3.132)
Pathological N stage		<0.001		<0.001
Negative(NX, N0)	1
Positive(N1, N2, N3)	1.365(1.141–2.388)		1.281(1.169–2.476)
Surgery		0.589
Nasal endoscopy	1
Nasal endoscopy + Lateral rhinotomy	1.257(0.614–3.845)
Albumin(>38.3/≤38.3, g/l)	1.219(0.511–1.546)	0.674
Hemoglobin(>128/≤128), g/dl)	0.452(0.261–1.578)	0.615
WBC count, (>8.34/≤8.34, 10^9/L)	1.274(0.215–1.659)	0.463
Neutrophil count, (>5.44/≤5.44, 10^9/L)	1.845(0.884–2.732)	0.547
Platelet count, (>198/≤198, 10^9/L)	1.633(0.815–2.442)	0.632
NLR		<0.001		<0.001
High (≤4.25)	1		1
Low(>4.25)	1.763(1.156–3.149)		1.688(1.162–3.363)

Abbreviations: BMI, Body Mass Index; NLR, neutrophil to lymphocyte ratio.

Table 4 Univariate And Multivariate Cox Hazards Analysis For DSS In Patients With SSCC

Varibles	Univariate Analysis		Multivariate Analysis
HR (95% CI)	p-value	HR (95% CI)	p-value
Age (years)		0.498
>58	1
≤58	0.436(0.201–1.555)
Gender		0.562
Male	1
Female	1.386(0.721–1.976)
Smoking status		0.027		0.814
Never smoked	1		1
Smoked in past	1.447(1.121–1.998)		0.802(0.314–1.853)
BMI(kg/m^2)		0.009		0.737
≤22.45	1		1
>22.45	1.435(1.028–1.953)		0.774(0.216–1.339)
Tumor size		0.625
≤2.5cm	1
>2.5cm	1.533(0.635–3.205)
Histological type		0.036		0.671
High	1		1
Medium, low	1.582(1.246–2.672)		1.378 (0.649–2.546)
Pathological T stage		<0.001		<0.001
T1, T2	1		1
T3, T4	1.453(1.259–3.133)		1.744(1.537–3.021)
Pathological N stage		<0.001		<0.001
Negative	1
Positive	1.477(1.204–2.142)		1.571(1.157–2.258)
Surgery		0.663
Nasal endoscopy	1
Nasal endoscopy + Lateral rhinotomy	1.514(0.735–3.333)
Albumin(>38.3/≤38.3, g/l)	1.646(0.621–1.879)	0.774
Hemoglobin(>128/≤128), g/dl)	0.601(0.315–1.449)	0.508
WBC count, (>8.34/≤8.34, 10^9/L)	1.443(0.301–1.877)	0.516
Neutrophil count, (>5.44/≤5.44, 10^9/L)	1.566(0.642–2.559)	0.688
Platelet count, (>198/≤198, 10^9/L)	1.753 (0.469–2.005)	0.594
NLR		<0.001		0.001
High (≤4.25)	1		1
Low(>4.25)	1.359(1.033–3.314)		1.509(1.153–3.104)

Abbreviations: BMI, Body Mass Index; NLR, neutrophil to lymphocyte ratio.