Risk Factors of Deterioration in Quality of Life Scores in Thyroid Cancer Patients After Thyroidectomy

Figures & data

Table 1 Demographic and Tumor Characteristics of 286 Participants (n, %)

Demographic Characteristics	(n, %)	Tumor Characteristics	(n, %)
Gender		Histology
Male	60 (21.0%)	Papillary	258 (90.2%)
Female	226 (79.0%)	Follicular	24 (8.4%)
Age (year)		Medullary	4 (1.4%)
≤60	238 (83.2%)	Clinical stage (AJCC8)
>60	48 (16.8%)	I	237 (82.8%)
Education		II	42 (14.7%)
Low (<12 years)	239 (83.6%)	III	6 (2.1%)
High (≥12 years)	47 (16.4%)	IV	1 (0.4%)
Marital status		Presence of metastasis
Married	232 (82.9%)	Yes	1 (0.4%)
Unmarried/divorced	49 (17.1%)	No	285 (99.6%)
Area of residence		Surgery type
City	87 (30.4%)	Lobectomy	194 (67.8%)
Rural or regional	199 (69.6%)	Total thyroidectomy	92 (32.2%)
Annual mean income		Radiotherapy
Low	76 (26.6%)	Yes	19 (6.6%)
Middle	155 (54.2%)	No	267(93.4%)
High	55 (19.2%)	Neurological deficits
		Yes	11 (3.8%)
		No	275 (96.2%)

Abbreviation: AJCC8, The 8th Edition of the American Joint Committee on Cancer.

Table 2 Logistic Regression Analyses of Factors Associated with Decreased QoL

	B Coefficient	Standard Error	P value	Beta	95% Confidence Interval for B
Clinical stage	−10.569	0.729	<0.001	−0.555	−12.003 – −9.135
Surgery type	−4.179	0.688	<0.001	−0.217	−5.533 – −2.824
Histology	−6.340	0.888	<0.001	−0.252	−8.089 – −4.591
Neurological deficits	−8.472	1.802	<0.001	−0.181	−12.019 – −4.925
Marital status	−3.417	0.893	<0.001	−0.143	−5.176 – −1.659

Abbreviation: QoL, Quality of life.

Table 3 QoL at 3 Months After Thyroidectomy on the Basis of the Risk Factors

	QoL Score	P
Clinical stage (AJCC8)		<0.001
I	70.60 (7.73)
II	54.62 (12.31)
III and IV	38.12 (5.64)
Surgery type		<0.001
Lobectomy	70.60 (6.92)
Total thyroidectomy	66.16 (15.55)
Histology		<0.001
Papillary	70.41 (7.04)
Follicular and Medullary	55.41 (13.84)
Neurological deficits		<0.001
Yes	45.77 (6.75)
No	70.09 (8.16)
Marital status		<0.001
Married	70.60 (5.75)
Unmarried/divorced	57.91 (13.17)

Note: Continuous variables are presented as median (interquartile range) due to abnormal distribution.

Abbreviations: QoL, Quality of life; AJCC8, The 8th Edition of the American Joint Committee on Cancer.