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Cancer Management and Research Volume 12, 2020 - Issue
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Original Research

Tyrosine Kinase Inhibitor-Related Hepatotoxicity in Patients with Advanced Lung Adenocarcinoma: A Real-World Retrospective Study

Jie Qian1 Department of Emergency Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of China;2 Department of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-2464-3006
ORCID Icon,
Xueyan Zhang2 Department of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of China
,
Bo Zhang2 Department of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of China
,
Bo Yan2 Department of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of China
,
Lin Wang3 Department of Laboratory Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of China
,
Ping Gu2 Department of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of China
,
Weimin Wang2 Department of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of China
,
Huimin Wang2 Department of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of China
&
Baohui Han2 Department of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of ChinaCorrespondence[email protected]
 show all
Pages 3293-3299 | Published online: 11 May 2020

Figures & data

Table 1 Patient Demographics and Baseline Characteristics

Figure 1 Characteristics of hepatotoxicity in patients receiving first-line EGFR-TKIs.

Figure 1 Characteristics of hepatotoxicity in patients receiving first-line EGFR-TKIs.

Figure 2 Onset time of EGFR-TKI-induced hepatotoxicity.

Figure 2 Onset time of EGFR-TKI-induced hepatotoxicity.

Table 2 Logistic Regression Analysis for Hepatic Toxicity in Patients Undergoing First-Line EGFR-TKI Treatment

Table 3 Multivariate Logistic Analysis Comparing Hepatotoxicity Among Different EGFR-TKI Agent

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