The Clinical Diagnostic and Prognostic Value of Dickkopf-1 in Cancer

Figures & data

Table 1 Different Expression of Serum DKK1 in Different Cancers

Studies	N	Cancer Types	n	DKK1, ng/mL	P	Methods
Aufderklamm et al at 2018^Citation21	143	Benign prostatic hyperplasia (BPH)	53	2.81	p<0.01	ELISA
		PC with metastasis (PC cM1)	47	2.58	P=0.01
		Localized PC (PC cM0)	43	1.55
Sheng et al at 2009^Citation19	404	Lung cancer	212	30.1	p<0.001	ELISA TR-IFMA
		Benign lung disease	72	15.3	P=0.24
		Healthy controls	120	13.9
Dong et al at 2014^Citation14	300	NSCLC	150	31.42±6.32	p<0.01	ELISA
		Healthy controls	150	14.12±3.29
Sun et al at 2015^Citation20	154	Bladder cancer	94	35.91±16.09	p<0.001	ELISA
		Healthy controls	60	9.08±5.21
Kim et al at 2015^Citation18	370	Hepatocellular carcinoma	217	1.48	p<0.01	ELISA
		Healthy controls	153	0.9
Jiang et al at 2013^Citation16	276	Healthy controls	60	1.48		ELISA
		CIN	60	4.77	P=0.00
		Cervical cancer	156	11.90	P = 0.00
Feng et al at 2018^Citation15	103	Multiple myeloma	58	Higher	p<0.01	ELISA IHC
		Healthy controls	45
Kasoha et al at 2018^Citation17	175	Breast patients with primary tumor	69	2.85(1.78–8.2)	p<0.001	ELISA
		Breast patients with bone metastases	20	3.5(1.29–5.46)	p<0.001
		Healthy women	86	1.9(0.79–0.52)

Note: p-value: Cancer group vs Healthy controls.

Aufderklamm S, Hennenlotter J, Leidenberger P, et al. Systemic alterations of Wnt inhibitors in patients with prostate cancer and bone metastases. Dis Markers. 2018;2018:1874598. doi:10.1155/2018/187459830116403

 PubMed Web of Science ®Google Scholar

Sheng SL, Huang G, Yu B, Qin WX. Clinical significance and prognostic value of serum Dickkopf-1 concentrations in patients with lung cancer. Clin Chem. 2009;55(9):1656–1664. doi:10.1373/clinchem.2009.12564119628661

 PubMed Web of Science ®Google Scholar

Dong LL, Qu LY, Chu LY, Zhang XH, Liu YH. Serum level of DKK-1 and its prognostic potential in non-small cell lung cancer. Diagn Pathol. 2014;9(1):52. doi:10.1186/1746-1596-9-5224612589

 PubMedGoogle Scholar

Sun DK, Wang L, Wang JM, Zhang P. Serum Dickkopf-1 levels as a clinical and prognostic factor in patients with bladder cancer. Genet Mol Res GMR. 2015;14(4):18181–18187. doi:10.4238/2015.December.23.526782465

 PubMed Web of Science ®Google Scholar

Kim SU, Park JH, Kim HS, et al. Serum Dickkopf-1 as a biomarker for the diagnosis of hepatocellular carcinoma. Yonsei Med J. 2015;56(5):1296–1306. doi:10.3349/ymj.2015.56.5.129626256972

 PubMed Web of Science ®Google Scholar

Jiang T, Huang L, Zhang S. DKK-1 in serum as a clinical and prognostic factor in patients with cervical cancer. Int J Biol Markers. 2013;28(2):221–225. doi:10.5301/jbm.500000523595579

 PubMed Web of Science ®Google Scholar

Feng Y, Zhang Y, Wei X, Zhang Q. Correlations of DKK1 with pathogenesis and prognosis of human multiple myeloma. Cancer Biomarkers Sect a Dis Markers. 2019;24(2):195–201. doi:10.3233/CBM-181909

 PubMed Web of Science ®Google Scholar

Kasoha M, Bohle RM, Seibold A, Gerlinger C, Juhasz-Böss I, Solomayer EF. Dickkopf-1 (Dkk1) protein expression in breast cancer with special reference to bone metastases. Clin Exp Metastasis. 2018;35(8):763–775. doi:10.1007/s10585-018-9937-330238177

 PubMed Web of Science ®Google Scholar